1vaf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1vaf.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1vaf.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1vaf| PDB=1vaf | SCENE= }}
{{STRUCTURE_1vaf| PDB=1vaf | SCENE= }}
-
'''Inducible nitric oxide synthase oxygenase domain complexed with the inhibitor AR-R17477'''
+
===Inducible nitric oxide synthase oxygenase domain complexed with the inhibitor AR-R17477===
-
==Overview==
+
<!--
-
The high level of amino acid conservation and structural similarity of the substrate-binding sites of the oxygenase domains of the nitric oxide synthase (NOS) isoforms (eNOSoxy, iNOSoxy, nNOSoxy) make the interpretation of the structural basis of inhibitor isoform specificity a challenge, and provide few clues for the design of new selective compounds. Crystal structures of iNOSoxy and nNOSoxy complexed with the neuronal NOS-specific inhibitor AR-R17447 suggest that specificity is provided by the interaction of the chlorophenyl group with an isoform-unique substrate access channel residue (L337 in rat neuronal NOS, N115 in mouse inducible NOS). This is confirmed by biochemical analysis of site-directed mutants. Inhibitors combining guanidinium-like structural motifs with long chains specifically targeting this residue are good candidates for rational isoform-specific drug design. Based on this finding, modifications of AR-R17447 to improve the specificity for the human isoforms are suggested.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15071192}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15071192 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15071192}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Vasan, R.]]
[[Category: Vasan, R.]]
[[Category: Murine inosoxy inhibitor complex]]
[[Category: Murine inosoxy inhibitor complex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:17:58 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:15:02 2008''

Revision as of 17:15, 28 July 2008

Image:1vaf.png

Template:STRUCTURE 1vaf

Inducible nitric oxide synthase oxygenase domain complexed with the inhibitor AR-R17477

Template:ABSTRACT PUBMED 15071192

About this Structure

1VAF is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structures of nitric oxide synthase isoforms complexed with the inhibitor AR-R17477 suggest a rational basis for specificity and inhibitor design., Fedorov R, Vasan R, Ghosh DK, Schlichting I, Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5892-7. Epub 2004 Apr 7. PMID:15071192

Page seeded by OCA on Mon Jul 28 20:15:02 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1vaf"
Personal tools