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1vb8

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[[Image:1vb8.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1vb8| PDB=1vb8 | SCENE= }}
{{STRUCTURE_1vb8| PDB=1vb8 | SCENE= }}
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'''solution structure of vhr1, the first cyclotide from root tissue'''
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===solution structure of vhr1, the first cyclotide from root tissue===
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==Overview==
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The plant cyclotides are a family of 28 to 37 amino acid miniproteins characterized by their head-to-tail cyclized peptide backbone and six absolutely conserved Cys residues arranged in a cystine knot motif: two disulfide bonds and the connecting backbone segments form a loop that is penetrated by the third disulfide bond. This knotted disulfide arrangement, together with the cyclic peptide backbone, renders the cyclotides extremely stable against enzymatic digest as well as thermal degradation, making them interesting targets for both pharmaceutical and agrochemical applications. We have examined the expression patterns of these fascinating peptides in various Viola species (Violaceae). All tissue types examined contained complex mixtures of cyclotides, with individual profiles differing significantly. We provide evidence for at least 57 novel cyclotides present in a single Viola species (Viola hederacea). Furthermore, we have isolated one cyclotide expressed only in underground parts of V. hederacea and characterized its primary and three-dimensional structure. We propose that cyclotides constitute a new family of plant defense peptides, which might constitute an even larger and, in their biological function, more diverse family than the well-known plant defensins.
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The line below this paragraph, {{ABSTRACT_PUBMED_15295104}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15295104 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15295104}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VB8 OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VB8 OCA].
==Reference==
==Reference==
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[[Category: Cystine knot]]
[[Category: Cystine knot]]
[[Category: Viola]]
[[Category: Viola]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:19:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:12:23 2008''

Revision as of 13:12, 27 July 2008

Image:1vb8.png

Template:STRUCTURE 1vb8

solution structure of vhr1, the first cyclotide from root tissue

Template:ABSTRACT PUBMED 15295104

About this Structure

Full experimental information is available from OCA.

Reference

Tissue-specific expression of head-to-tail cyclized miniproteins in Violaceae and structure determination of the root cyclotide Viola hederacea root cyclotide1., Trabi M, Craik DJ, Plant Cell. 2004 Aug;16(8):2204-16. PMID:15295104

Page seeded by OCA on Sun Jul 27 16:12:23 2008

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