1vdd

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{{STRUCTURE_1vdd| PDB=1vdd | SCENE= }}
{{STRUCTURE_1vdd| PDB=1vdd | SCENE= }}
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'''Crystal structure of recombinational repair protein RecR'''
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===Crystal structure of recombinational repair protein RecR===
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==Overview==
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RecR, together with RecF and RecO, facilitates RecA loading in the RecF pathway of homologous recombinational DNA repair in procaryotes. The human Rad52 protein is a functional counterpart of RecFOR. We present here the crystal structure of RecR from Deinococcus radiodurans (DR RecR). A monomer of DR RecR has a two-domain structure: the N-terminal domain with a helix-hairpin-helix (HhH) motif and the C-terminal domain with a Cys4 zinc-finger motif, a Toprim domain and a Walker B motif. Four such monomers form a ring-shaped tetramer of 222 symmetry with a central hole of 30-35 angstroms diameter. In the crystal, two tetramers are concatenated, implying that the RecR tetramer is capable of opening and closing. We also show that DR RecR binds to both dsDNA and ssDNA, and that its HhH motif is essential for DNA binding.
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(as it appears on PubMed at http://www.pubmed.gov), where 15116069 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15116069}}
==About this Structure==
==About this Structure==
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[[Category: Walker b atp binding motif]]
[[Category: Walker b atp binding motif]]
[[Category: Zinc finger]]
[[Category: Zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:24:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:39:53 2008''

Revision as of 11:39, 27 July 2008

Image:1vdd.png

Template:STRUCTURE 1vdd

Crystal structure of recombinational repair protein RecR

Template:ABSTRACT PUBMED 15116069

About this Structure

1VDD is a Single protein structure of sequence from Deinococcus radiodurans. Full crystallographic information is available from OCA.

Reference

Ring-shaped architecture of RecR: implications for its role in homologous recombinational DNA repair., Lee BI, Kim KH, Park SJ, Eom SH, Song HK, Suh SW, EMBO J. 2004 May 19;23(10):2029-38. Epub 2004 Apr 29. PMID:15116069

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