1vde

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[[Image:1vde.gif|left|200px]]
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{{STRUCTURE_1vde| PDB=1vde | SCENE= }}
{{STRUCTURE_1vde| PDB=1vde | SCENE= }}
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'''PI-SCEI, A HOMING ENDONUCLEASE WITH PROTEIN SPLICING ACTIVITY'''
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===PI-SCEI, A HOMING ENDONUCLEASE WITH PROTEIN SPLICING ACTIVITY===
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==Overview==
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PI-Scel is a bifunctional yeast protein that propagates its mobile gene by catalyzing protein splicing and site-specific DNA double-strand cleavage. Here, we report the 2.4 A crystal structure of the PI-Scel protein. The structure is composed of two separate domains (I and II) with novel folds and different functions. Domain I, which is elongated and formed largely from seven beta sheets, harbors the N and C termini residues and two His residues that are implicated in protein splicing. Domain II, which is compact and is primarily composed of two similar alpha/beta motifs related by local two-fold symmetry, contains the putative nuclease active site with a cluster of two acidic residues and one basic residue commonly found in restriction endonucleases. This report presents prototypic structures of domains with single endonuclease and protein splicing active sites.
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(as it appears on PubMed at http://www.pubmed.gov), where 9160747 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9160747}}
==About this Structure==
==About this Structure==
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[[Category: Homing endonuclease]]
[[Category: Homing endonuclease]]
[[Category: Protein splicing]]
[[Category: Protein splicing]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:24:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:43:44 2008''

Revision as of 20:43, 27 July 2008

Image:1vde.png

Template:STRUCTURE 1vde

PI-SCEI, A HOMING ENDONUCLEASE WITH PROTEIN SPLICING ACTIVITY

Template:ABSTRACT PUBMED 9160747

About this Structure

1VDE is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of PI-SceI, a homing endonuclease with protein splicing activity., Duan X, Gimble FS, Quiocho FA, Cell. 1997 May 16;89(4):555-64. PMID:9160747

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