Sandbox Reserved 1849

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====Structure====
====Structure====
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<p>The <scene name='10/1075251/Spike_protein_closed_spacefill/2'>spike protein</scene> of SARS-COV-2 is a symmetric trimer featuring 3 spike glycoprotein chains (UNIPROT: [https://www.uniprot.org/uniprotkb/P0DTC2/entry P0DTC2])
+
<p>The <scene name='10/1075251/Spike_protein_closed_spacefill/2'>spike protein</scene> of SARS-COV-2 is a symmetric trimer featuring 3 spike glycoprotein chains (UNIPROT: [https://www.uniprot.org/uniprotkb/P0DTC2/entry P0DTC2]). Each monomer of the spike is called a spike glycoprotein, and it contains 2 main parts: The S1 and S2 subunits. The S2 subunit
</p>
</p>
====Function====
====Function====
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</StructureSection>
</StructureSection>
== References ==
== References ==
 +
<ref name="Huang">DOI:10.1038/s41401-020-0485-4</ref>
<references/>
<references/>

Revision as of 17:01, 3 April 2025

This Sandbox is Reserved from March 18 through September 1, 2025 for use in the course CH462 Biochemistry II taught by R. Jeremy Johnson and Mark Macbeth at the Butler University, Indianapolis, USA. This reservation includes Sandbox Reserved 1828 through Sandbox Reserved 1846.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

SARS-COV2 Minibinders

LCB1 (PDB:7JZU) | An example of a novel minibinder, LCB1 (Blue), bound to the spike RBD of SARS-COV-2 (Off-White)

Drag the structure with the mouse to rotate

References

[3]

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
  3. ↑ Huang Y, Yang C, Xu XF, Xu W, Liu SW. Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19. Acta Pharmacol Sin. 2020 Sep;41(9):1141-1149. doi: 10.1038/s41401-020-0485-4., Epub 2020 Aug 3. PMID:32747721 doi:http://dx.doi.org/10.1038/s41401-020-0485-4
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