User:Matthew Pereira/Sandbox 1
From Proteopedia
(Difference between revisions)
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[https://en.wikipedia.org/wiki/COVID-19 COVID-19] | [https://en.wikipedia.org/wiki/COVID-19 COVID-19] | ||
==Function== | ==Function== | ||
| - | The minibinder associates with the SARS-CoV-2 spike protein | + | The minibinder associates with the SARS-CoV-2 spike protein binding domain for ACE-2 before it reaches a host cell. <scene name='10/1075220/Spikeblockedbyminibinder/1'>This prevents association with ACE-2.</scene> |
==Stability== | ==Stability== | ||
[[Image:minibinder_with_surface.png|400 px|left|thumb|Placeholder Image to be Replaced]] Structure sourced from original source paper Longxing et al.<ref name="Longxing">PMID:32907861</ref> | [[Image:minibinder_with_surface.png|400 px|left|thumb|Placeholder Image to be Replaced]] Structure sourced from original source paper Longxing et al.<ref name="Longxing">PMID:32907861</ref> | ||
Revision as of 19:20, 1 April 2025
SARS-CoV-2 De Novo Designed Minibinders
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References
- ↑ Cao L, Goreshnik I, Coventry B, Case JB, Miller L, Kozodoy L, Chen RE, Carter L, Walls AC, Park YJ, Strauch EM, Stewart L, Diamond MS, Veesler D, Baker D. De novo design of picomolar SARS-CoV-2 miniprotein inhibitors. Science. 2020 Oct 23;370(6515):426-431. PMID:32907861 doi:10.1126/science.abd9909
Student Contributors
Matt Pereira, Giavanna Yowel, and Shae Bailey
