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1ve7

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{{STRUCTURE_1ve7| PDB=1ve7 | SCENE= }}
{{STRUCTURE_1ve7| PDB=1ve7 | SCENE= }}
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'''Crystal structure of an acylpeptide hydrolase/esterase from Aeropyrum pernix K1 in complex with p-nitrophenyl phosphate'''
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===Crystal structure of an acylpeptide hydrolase/esterase from Aeropyrum pernix K1 in complex with p-nitrophenyl phosphate===
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==Overview==
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Acylpeptide hydrolases (APH; also known as acylamino acid releasing enzyme) catalyze the removal of an N-acylated amino acid from blocked peptides. The crystal structure of an APH from the thermophilic archaeon Aeropyrum pernix K1 to 2.1 A resolution confirms it to be a member of the prolyl oligopeptidase family of serine proteases. The structure of apAPH is a symmetric homodimer with each subunit comprised of two domains. The N-terminal domain is a regular seven-bladed beta-propeller, while the C-terminal domain has a canonical alpha/beta hydrolase fold and includes the active site and a conserved Ser445-Asp524-His556 catalytic triad. The complex structure of apAPH with an organophosphorus substrate, p-nitrophenyl phosphate, has also been determined. The complex structure unambiguously maps out the substrate binding pocket and provides a basis for substrate recognition by apAPH. A conserved mechanism for protein degradation from archaea to mammals is suggested by the structural features of apAPH.
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{{ABSTRACT_PUBMED_15296741}}
==About this Structure==
==About this Structure==
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[[Category: Alpha/beta hydrolase domain]]
[[Category: Alpha/beta hydrolase domain]]
[[Category: Beta propeller domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:26:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:56:50 2008''

Revision as of 15:56, 28 July 2008

Image:1ve7.png

Template:STRUCTURE 1ve7

Crystal structure of an acylpeptide hydrolase/esterase from Aeropyrum pernix K1 in complex with p-nitrophenyl phosphate

Template:ABSTRACT PUBMED 15296741

About this Structure

1VE7 is a Single protein structure of sequence from Aeropyrum pernix. Full crystallographic information is available from OCA.

Reference

Crystal structure of an acylpeptide hydrolase/esterase from Aeropyrum pernix K1., Bartlam M, Wang G, Yang H, Gao R, Zhao X, Xie G, Cao S, Feng Y, Rao Z, Structure. 2004 Aug;12(8):1481-8. PMID:15296741

Page seeded by OCA on Mon Jul 28 18:56:50 2008

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