9qnv

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m (Protected "9qnv" [edit=sysop:move=sysop])
Current revision (05:50, 14 May 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9qnv is ON HOLD
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==CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX with compound 2==
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<StructureSection load='9qnv' size='340' side='right'caption='[[9qnv]], [[Resolution|resolution]] 1.23&Aring;' scene=''>
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Authors: Krojer, T., Martinez-Cartro, M., Picaud, S., Filippakopoulos, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Barril, X., von Delft, F., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9qnv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QNV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9QNV FirstGlance]. <br>
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Description: CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX with compound 2
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.226&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1I76:3-methyl-5-phenyl-[1,3]thiazolo[2,3-c][1,2,4]triazole'>A1I76</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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[[Category: Filippakopoulos, P]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9qnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9qnv OCA], [https://pdbe.org/9qnv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9qnv RCSB], [https://www.ebi.ac.uk/pdbsum/9qnv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9qnv ProSAT]</span></td></tr>
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[[Category: Edwards, A.M]]
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</table>
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[[Category: Krojer, T]]
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== Disease ==
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[[Category: Von Delft, F]]
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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[[Category: Arrowsmith, C.H]]
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== Function ==
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[[Category: Barril, X]]
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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[[Category: Picaud, S]]
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== References ==
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[[Category: Bountra, C]]
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<references/>
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[[Category: Martinez-Cartro, M]]
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__TOC__
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[[Category: Structural Genomics Consortium (Sgc)]]
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Barril X]]
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[[Category: Bountra C]]
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[[Category: Edwards AM]]
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[[Category: Filippakopoulos P]]
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[[Category: Krojer T]]
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[[Category: Martinez-Cartro M]]
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[[Category: Picaud S]]
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[[Category: Von Delft F]]

Current revision

CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX with compound 2

PDB ID 9qnv

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