1ves

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{{STRUCTURE_1ves| PDB=1ves | SCENE= }}
{{STRUCTURE_1ves| PDB=1ves | SCENE= }}
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'''Structure of New Antigen Receptor variable domain from sharks'''
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===Structure of New Antigen Receptor variable domain from sharks===
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==Overview==
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The Ig new antigen receptors (IgNARs) are single-domain antibodies found in the serum of sharks. Here, we report 2.2- and 2.8-A structures of the type 2 IgNAR variable domains 12Y-1 and 12Y-2. Structural features include, first, an Ig superfamily topology transitional between cell adhesion molecules, antibodies, and T cell receptors; and, second, a vestigial complementarity-determining region 2 at the "bottom" of the molecule, apparently discontinuous from the antigen-binding paratope and similar to that observed in cell adhesion molecules. Thus, we suggest that IgNARs originated as cell-surface adhesion molecules coopted to the immune repertoire and represent an evolutionary lineage independent of variable heavy chain/variable light chain type antibodies. Additionally, both 12Y-1 and 12Y-2 form unique crystallographic dimers, predominantly mediated by main-chain framework interactions, which represent a possible model for primordial cell-based interactions. Unusually, the 12Y-2 complementarity-determining region 3 also adopts an extended beta-hairpin structure, suggesting a distinct selective advantage in accessing cryptic antigenic epitopes.
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The line below this paragraph, {{ABSTRACT_PUBMED_15304650}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15304650 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15304650}}
==About this Structure==
==About this Structure==
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[[Category: 12y-2]]
[[Category: 12y-2]]
[[Category: Ig vnar]]
[[Category: Ig vnar]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:27:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:07:40 2008''

Revision as of 06:07, 28 July 2008

Image:1ves.png

Template:STRUCTURE 1ves

Structure of New Antigen Receptor variable domain from sharks

Template:ABSTRACT PUBMED 15304650

About this Structure

1VES is a Single protein structure of sequence from Orectolobus maculatus. Full crystallographic information is available from OCA.

Reference

Structural evidence for evolution of shark Ig new antigen receptor variable domain antibodies from a cell-surface receptor., Streltsov VA, Varghese JN, Carmichael JA, Irving RA, Hudson PJ, Nuttall SD, Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12444-9. Epub 2004 Aug 10. PMID:15304650

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