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1vfi

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[[Image:1vfi.gif|left|200px]]
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{{STRUCTURE_1vfi| PDB=1vfi | SCENE= }}
{{STRUCTURE_1vfi| PDB=1vfi | SCENE= }}
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'''Solution Structure of Vanabin2 (RUH-017), a Vanadium-binding Protein from Ascidia sydneiensis samea'''
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===Solution Structure of Vanabin2 (RUH-017), a Vanadium-binding Protein from Ascidia sydneiensis samea===
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==Overview==
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Ascidians belonging to the suborder Phlebobranchia are known to accumulate high levels of a transition metal, vanadium, in their blood cells, called vanadocytes, although the mechanism for this biological phenomenon remains unclear. Recently, we identified vanadium(IV)-binding proteins, designated as Vanabins, from vanadium-accumulating ascidians. Here, we report the first 3D structure of Vanabin2 from an ascidian, Ascidia sydneiensis samea, in an aqueous solution. The structure revealed a novel bow-shaped conformation, with four alpha-helices connected by nine disulfide bonds. There are no structural homologues reported so far. The 15N heteronuclear single-quantum coherence (HSQC) perturbation experiments of Vanabin2 indicated that vanadyl cations, which are exclusively localized on the same face of the molecule, are coordinated by amine nitrogens derived from amino acid residues such as lysines, arginines, and histidines, as suggested by the electron paramagnetic resonance (EPR) results. The present NMR studies provide information that will contribute toward elucidating the mechanism of vanadium accumulation in ascidians.
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{{ABSTRACT_PUBMED_15783203}}
==About this Structure==
==About this Structure==
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1VFI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ascidia_sydneiensis_samea Ascidia sydneiensis samea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VFI OCA].
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1VFI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ascidia_sydneiensis_samea Ascidia sydneiensis samea]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VFI OCA].
==Reference==
==Reference==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Vanadium-binding]]
[[Category: Vanadium-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:28:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:29:45 2008''

Revision as of 12:29, 28 July 2008

Image:1vfi.png

Template:STRUCTURE 1vfi

Solution Structure of Vanabin2 (RUH-017), a Vanadium-binding Protein from Ascidia sydneiensis samea

Template:ABSTRACT PUBMED 15783203

About this Structure

1VFI is a Single protein structure of sequence from Ascidia sydneiensis samea. Full experimental information is available from OCA.

Reference

Solution structure of Vanabin2, a vanadium(IV)-binding protein from the vanadium-rich ascidian Ascidia sydneiensis samea., Hamada T, Asanuma M, Ueki T, Hayashi F, Kobayashi N, Yokoyama S, Michibata H, Hirota H, J Am Chem Soc. 2005 Mar 30;127(12):4216-22. PMID:15783203

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