9m4p
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of alpha-hemolysin heptameric pore state in the presence of RBC== | |
| - | + | <StructureSection load='9m4p' size='340' side='right'caption='[[9m4p]], [[Resolution|resolution]] 3.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9m4p]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9M4P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9M4P FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9m4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9m4p OCA], [https://pdbe.org/9m4p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9m4p RCSB], [https://www.ebi.ac.uk/pdbsum/9m4p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9m4p ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Chatterjee | + | == Function == |
| - | [[Category: Dutta | + | [https://www.uniprot.org/uniprot/HLA_STAAU HLA_STAAU] Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity. |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Staphylococcus aureus]] | ||
| + | [[Category: Chatterjee A]] | ||
| + | [[Category: Dutta S]] | ||
| + | [[Category: Roy A]] | ||
Current revision
Cryo-EM structure of alpha-hemolysin heptameric pore state in the presence of RBC
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