9o52

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m (Protected "9o52" [edit=sysop:move=sysop])
Current revision (16:27, 9 July 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9o52 is ON HOLD until Paper Publication
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==Cryo-EM structure of the human SK2-4 chimera/calmodulin channel complex bound to the bee toxin apamin==
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<StructureSection load='9o52' size='340' side='right'caption='[[9o52]], [[Resolution|resolution]] 3.18&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9o52]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Apis_mellifera Apis mellifera] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9O52 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9O52 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.18&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9o52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9o52 OCA], [https://pdbe.org/9o52 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9o52 RCSB], [https://www.ebi.ac.uk/pdbsum/9o52 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9o52 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/KCNN4_HUMAN KCNN4_HUMAN] The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/KCNN2_HUMAN KCNN2_HUMAN] Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.[https://www.uniprot.org/uniprot/KCNN4_HUMAN KCNN4_HUMAN] Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin (PubMed:17157250, PubMed:18796614).<ref>PMID:17157250</ref> <ref>PMID:18796614</ref> <ref>PMID:26148990</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Apis mellifera]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Cassell SJ]]
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[[Category: Khoshouei M]]
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[[Category: Whicher JR]]
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[[Category: Wilhelm WA]]

Current revision

Cryo-EM structure of the human SK2-4 chimera/calmodulin channel complex bound to the bee toxin apamin

PDB ID 9o52

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