9m4q

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Current revision (05:34, 3 July 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9m4q is ON HOLD until Paper Publication
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==CryoEM structure of the alpha1AAR complex with doxazosin==
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<StructureSection load='9m4q' size='340' side='right'caption='[[9m4q]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
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Authors: Liu, S.S., Guo, Q., Tao, Y.Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9m4q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9M4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9M4Q FirstGlance]. <br>
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Description: CryoEM structure of the the alpha1AAR complex with doxazosin
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.99&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EM4:[4-(4-azanyl-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-[(3~{S})-2,3-dihydro-1,4-benzodioxin-3-yl]methanone'>A1EM4</scene></td></tr>
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[[Category: Guo, Q]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9m4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9m4q OCA], [https://pdbe.org/9m4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9m4q RCSB], [https://www.ebi.ac.uk/pdbsum/9m4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9m4q ProSAT]</span></td></tr>
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[[Category: Liu, S.S]]
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</table>
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[[Category: Tao, Y.Y]]
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== Function ==
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[https://www.uniprot.org/uniprot/ADA1A_HUMAN ADA1A_HUMAN] This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.<ref>PMID:18802028</ref> <ref>PMID:22120526</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Guo Q]]
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[[Category: Jiao HZ]]
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[[Category: Liu SS]]
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[[Category: Tao YY]]
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[[Category: Wang DD]]

Current revision

CryoEM structure of the alpha1AAR complex with doxazosin

PDB ID 9m4q

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OCA

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