9ncq

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Current revision (09:37, 6 November 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9ncq is ON HOLD until Paper Publication
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==Cryo-EM structure of Fas-FADD complex==
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<StructureSection load='9ncq' size='340' side='right'caption='[[9ncq]], [[Resolution|resolution]] 3.51&Aring;' scene=''>
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Authors: Fosuah, E., Lin, Q., Shen, Z., Fu, T.M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9ncq]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NCQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NCQ FirstGlance]. <br>
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Description: Cryo-EM structure of Fas-FADD complex
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.51&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ncq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ncq OCA], [https://pdbe.org/9ncq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ncq RCSB], [https://www.ebi.ac.uk/pdbsum/9ncq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ncq ProSAT]</span></td></tr>
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[[Category: Shen, Z]]
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</table>
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[[Category: Fosuah, E]]
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== Disease ==
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[[Category: Lin, Q]]
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[https://www.uniprot.org/uniprot/TNR6_HUMAN TNR6_HUMAN] Defects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:[https://omim.org/entry/601859 601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.<ref>PMID:17336828</ref> <ref>PMID:7540117</ref> <ref>PMID:8929361</ref> <ref>PMID:9028321</ref> <ref>PMID:9028957</ref> <ref>PMID:9322534</ref> <ref>PMID:9821419</ref> <ref>PMID:10090885</ref> <ref>PMID:10515860</ref> <ref>PMID:10340403</ref> <ref>PMID:9927496</ref> <ref>PMID:11418480</ref> <ref>PMID:20935634</ref>
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[[Category: Fu, T.M]]
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== Function ==
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[https://www.uniprot.org/uniprot/TNR6_HUMAN TNR6_HUMAN] Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).<ref>PMID:7533181</ref> <ref>PMID:19118384</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Fosuah E]]
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[[Category: Fu TM]]
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[[Category: Lin Q]]
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[[Category: Shen Z]]

Current revision

Cryo-EM structure of Fas-FADD complex

PDB ID 9ncq

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OCA

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