9nsx

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Current revision (05:49, 6 August 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9nsx is ON HOLD until Paper Publication
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==OXA-23-NA-1-157, 3 minute soak==
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<StructureSection load='9nsx' size='340' side='right'caption='[[9nsx]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
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Authors: Smith, C.A., Toth, M., Stewart, N.K., Vakulenko, S.B.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9nsx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NSX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NSX FirstGlance]. <br>
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Description: OXA-23-NA-1-157, 3 minute soak
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.57&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=Y33:(2~{R})-2-[(2~{S},3~{R})-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-[(3~{S},5~{S})-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-2-methyl-1,3-dihydropyrrole-5-carboxylic+acid'>Y33</scene></td></tr>
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[[Category: Smith, C.A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9nsx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9nsx OCA], [https://pdbe.org/9nsx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9nsx RCSB], [https://www.ebi.ac.uk/pdbsum/9nsx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9nsx ProSAT]</span></td></tr>
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[[Category: Toth, M]]
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</table>
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[[Category: Stewart, N.K]]
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== Function ==
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[[Category: Vakulenko, S.B]]
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[https://www.uniprot.org/uniprot/BLO23_ACIBA BLO23_ACIBA] Class D beta-lactamase which confers resistance to the beta-lactam antibiotics, including ampicillin, and carbapenems such as imipenem and meropenem (PubMed:18725452, PubMed:20194701, PubMed:24012371, PubMed:30530607, PubMed:35420470). Acts via hydrolysis of the beta-lactam ring (PubMed:23877677, PubMed:24012371, PubMed:30530607, PubMed:35420470). Has penicillin-, cephalosporin- and carbapenem-hydrolyzing activities, but lacks ceftazidime-hydrolyzing activity (PubMed:23877677, PubMed:24012371, PubMed:30530607, PubMed:35420470).<ref>PMID:18725452</ref> <ref>PMID:20194701</ref> <ref>PMID:23877677</ref> <ref>PMID:24012371</ref> <ref>PMID:30530607</ref> <ref>PMID:35420470</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Acinetobacter baumannii]]
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[[Category: Large Structures]]
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[[Category: Smith CA]]
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[[Category: Stewart NK]]
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[[Category: Toth M]]
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[[Category: Vakulenko SB]]

Current revision

OXA-23-NA-1-157, 3 minute soak

PDB ID 9nsx

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