This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1vl3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1vl3.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1vl3.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1vl3| PDB=1vl3 | SCENE= }}
{{STRUCTURE_1vl3| PDB=1vl3 | SCENE= }}
-
'''DESIGN OF NEW MIMOCHROMES WITH UNIQUE TOPOLOGY'''
+
===DESIGN OF NEW MIMOCHROMES WITH UNIQUE TOPOLOGY===
-
==Overview==
+
<!--
-
Peptide-based metalloprotein models represent useful systems to help understand how metalloproteins can support different functions, by the use of similar metal ion cofactors. In order to shed light on the role of the protein matrix in modulating the heme properties, we developed new models: mimochromes. They are pseudo-C(2) symmetric systems, composed of two helical peptides covalently linked to the deuteroporphyrin. The use of C(2) symmetry is particularly advantageous, because it simplifies the design, synthesis and characterization. However, it leaves the problem of possible diastereomeric forms. In the cobalt complex of the first derivative, mimochrome I, Lambda and Delta isomers were indeed experimentally observed. All the insights derived from the Co(III)-mimochrome I structure were used to obtain a re-designed molecule, mimochrome IV. The spectroscopic characterization of the iron and cobalt derivatives suggested the presence of the Lambda isomer as unique species. The NMR solution structure of the diamagnetic Co(III)-mimochrome IV confirmed the ability of the molecule to adopt a unique topology, and revealed the peptide chains to be in helical conformation, as designed. The insertion of intramolecular, inter-chain interactions was successful in favoring the formation of one of the two possible diastereomers. The stereochemically stable structure of mimochrome IV provides an attractive model for modulating the redox potential of the heme, by simple changing the peptide chain composition around the heme.
+
The line below this paragraph, {{ABSTRACT_PUBMED_14639648}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 14639648 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_14639648}}
==About this Structure==
==About this Structure==
-
This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1l1b 1l1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VL3 OCA].
+
This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1l1b 1l1b]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VL3 OCA].
==Reference==
==Reference==
Line 32: Line 36:
[[Category: Design]]
[[Category: Design]]
[[Category: Miniaturized metalloprotein]]
[[Category: Miniaturized metalloprotein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:40:04 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:57:56 2008''

Revision as of 10:57, 28 July 2008

Image:1vl3.png

Template:STRUCTURE 1vl3

DESIGN OF NEW MIMOCHROMES WITH UNIQUE TOPOLOGY

Template:ABSTRACT PUBMED 14639648

About this Structure

This structure supersedes the now removed PDB entry 1l1b. Full experimental information is available from OCA.

Reference

Design of a new mimochrome with unique topology., Lombardi A, Nastri F, Marasco D, Maglio O, De Sanctis G, Sinibaldi F, Santucci R, Coletta M, Pavone V, Chemistry. 2003 Nov 21;9(22):5643-54. PMID:14639648

Page seeded by OCA on Mon Jul 28 13:57:56 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1vl3"
Personal tools