1vld

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1vld.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1vld.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1vld| PDB=1vld | SCENE= }}
{{STRUCTURE_1vld| PDB=1vld | SCENE= }}
-
'''Crystal Structure of Pyrogallol-Phloroglucinol Transhydroxylase from Pelobacter acidigallici'''
+
===Crystal Structure of Pyrogallol-Phloroglucinol Transhydroxylase from Pelobacter acidigallici===
-
==Overview==
+
<!--
-
The Mo enzyme transhydroxylase from the anaerobic microorganism Pelobacter acidigallici catalyzes the conversion of pyrogallol to phloroglucinol. Such trihydroxybenzenes and their derivatives represent important building blocks of plant polymers. None of the transferred hydroxyl groups originates from water during transhydroxylation; instead a cosubstrate, such as 1,2,3,5-tetrahydroxybenzene, is used in a reaction without apparent electron transfer. Here, we report on the crystal structure of the enzyme in the reduced Mo(IV) state, which we solved by single anomalous-diffraction technique. It represents the largest structure (1,149 amino acid residues per molecule, 12 independent molecules per unit cell), which has been solved so far by single anomalous-diffraction technique. Tranhydroxylase is a heterodimer, with the active Mo-molybdopterin guanine dinucleotide (MGD)(2) site in the alpha-subunit, and three [4Fe-4S] centers in the beta-subunit. The latter subunit carries a seven-stranded, mainly antiparallel beta-barrel domain. We propose a scheme for the transhydroxylation reaction based on 3D structures of complexes of the enzyme with various polyphenols serving either as substrate or inhibitor.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15284442}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15284442 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15284442}}
==About this Structure==
==About this Structure==
Line 33: Line 37:
[[Category: Mgd-cofactor]]
[[Category: Mgd-cofactor]]
[[Category: Molybdenum binding enzyme]]
[[Category: Molybdenum binding enzyme]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:40:41 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:00:14 2008''

Revision as of 11:00, 28 July 2008

Image:1vld.png

Template:STRUCTURE 1vld

Crystal Structure of Pyrogallol-Phloroglucinol Transhydroxylase from Pelobacter acidigallici

Template:ABSTRACT PUBMED 15284442

About this Structure

1VLD is a Protein complex structure of sequences from Pelobacter acidigallici. Full crystallographic information is available from OCA.

Reference

Crystal structure of pyrogallol-phloroglucinol transhydroxylase, an Mo enzyme capable of intermolecular hydroxyl transfer between phenols., Messerschmidt A, Niessen H, Abt D, Einsle O, Schink B, Kroneck PM, Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11571-6. Epub 2004 Jul 29. PMID:15284442

Page seeded by OCA on Mon Jul 28 14:00:14 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1vld"
Personal tools