User:Peyton Jenkins/Sandbox 1
From Proteopedia
(Difference between revisions)
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| - | == | + | ==2WTK: Hetertrimeric Complex of STK11, Mo25, and STRADa== |
| - | <StructureSection load=' | + | <StructureSection load='2WTK' size='340' side='right' caption='Heterotrimeric Complex of STK11, MO25, STRADα' scene=''> |
== Relevance and Disease == | == Relevance and Disease == | ||
Lung cancer is the leading cause of cancer related death worldwide. In the United States alone, over 120,000 deaths were caused by lung cancer in 2024<ref>https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2024/2024-cancer-facts-and-figures-acs.pdf</ref>. Non small cell lung cancer make up approximately 84% of all lung cancer cases, and of these lung adenocarcinoma accounts for about 65%<ref>10.1001/jamaoncol.2021.4932</ref>. In lung adenocarcinoma, ''STK11'' is the third most commonly mutated gene, behind only ''KRAS'' and ''p53''<ref>10.1091/mbc.E15-08-0569.</ref>. | Lung cancer is the leading cause of cancer related death worldwide. In the United States alone, over 120,000 deaths were caused by lung cancer in 2024<ref>https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2024/2024-cancer-facts-and-figures-acs.pdf</ref>. Non small cell lung cancer make up approximately 84% of all lung cancer cases, and of these lung adenocarcinoma accounts for about 65%<ref>10.1001/jamaoncol.2021.4932</ref>. In lung adenocarcinoma, ''STK11'' is the third most commonly mutated gene, behind only ''KRAS'' and ''p53''<ref>10.1091/mbc.E15-08-0569.</ref>. | ||
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== Structural Highlights == | == Structural Highlights == | ||
| - | The | + | '''STK11:''' The structure of STK11 can be broken up into three domain |
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 23:42, 26 April 2025
2WTK: Hetertrimeric Complex of STK11, Mo25, and STRADa
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