9u51
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of Mycobacterium tuberculosis MmpL5 in complex with AcpM== | |
| - | + | <StructureSection load='9u51' size='340' side='right'caption='[[9u51]], [[Resolution|resolution]] 3.05Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9u51]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv] and [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9U51 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9U51 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.05Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4HH:O-[(S)-HYDROXY{[(3R)-3-HYDROXY-2,2-DIMETHYL-4-OXO-4-({3-OXO-3-[(2-SULFANYLETHYL)AMINO]PROPYL}AMINO)BUTYL]OXY}PHOSPHORYL]-L-SERINE'>4HH</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9u51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9u51 OCA], [https://pdbe.org/9u51 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9u51 RCSB], [https://www.ebi.ac.uk/pdbsum/9u51 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9u51 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MMPL5_MYCTU MMPL5_MYCTU] Part of an export system, which is required for biosynthesis and secretion of siderophores.<ref>PMID:23431276</ref> Overexpression of the system confers non-target based resistance to azoles, clofazimine and bedaquiline, via an efflux mechanism.<ref>PMID:18851927</ref> <ref>PMID:24590481</ref> <ref>PMID:25010492</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
| + | [[Category: Mycolicibacterium smegmatis MC2 155]] | ||
| + | [[Category: Gao F]] | ||
| + | [[Category: Li D]] | ||
| + | [[Category: Ma X]] | ||
| + | [[Category: Zhang X]] | ||
Current revision
Cryo-EM structure of Mycobacterium tuberculosis MmpL5 in complex with AcpM
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