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1vps

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{{STRUCTURE_1vps| PDB=1vps | SCENE= }}
{{STRUCTURE_1vps| PDB=1vps | SCENE= }}
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'''POLYOMAVIRUS VP1 PENTAMER COMPLEXED WITH A DISIALYLATED HEXASACCHARIDE'''
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===POLYOMAVIRUS VP1 PENTAMER COMPLEXED WITH A DISIALYLATED HEXASACCHARIDE===
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==Overview==
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The crystal structure of a recombinant polyomavirus VP1 pentamer (residues 32-320) in complex with a branched disialylated hexasaccharide receptor fragment has been determined at 1.9 A resolution. The result extends our understanding of oligosaccharide receptor recognition. It also suggests a mechanism for enhancing the fidelity of virus assembly. We have previously described the structure of the complete polyomavirus particle complexed with this receptor fragment at 3.65 A. The model presented here offers a much more refined view of the interactions that determine carbohydrate recognition and allows us to assign additional specific contacts, in particular those involving the (alpha2,6)-linked, branching sialic acid. The structure of the unliganded VP1 pentamer, determined independently, shows that the oligosaccharide fits into a preformed groove and induces no measurable structural rearrangements. A comparison with assembled VP1 in the virus capsid reveals a rearrangement of residues 32-45 at the base of the pentamer. This segment may help prevent the formation of incorrectly assembled particles by reducing the likelihood that the C-terminal arm will fold back into its pentamer of origin.
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(as it appears on PubMed at http://www.pubmed.gov), where 9305654 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9305654}}
==About this Structure==
==About this Structure==
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[[Category: Virus assembly]]
[[Category: Virus assembly]]
[[Category: Virus coat protein]]
[[Category: Virus coat protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:46:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:48:25 2008''

Revision as of 18:48, 28 July 2008

Image:1vps.png

Template:STRUCTURE 1vps

POLYOMAVIRUS VP1 PENTAMER COMPLEXED WITH A DISIALYLATED HEXASACCHARIDE

Template:ABSTRACT PUBMED 9305654

About this Structure

1VPS is a Single protein structure of sequence from Murine polyomavirus. Full crystallographic information is available from OCA.

Reference

High-resolution structure of a polyomavirus VP1-oligosaccharide complex: implications for assembly and receptor binding., Stehle T, Harrison SC, EMBO J. 1997 Aug 15;16(16):5139-48. PMID:9305654

Page seeded by OCA on Mon Jul 28 21:48:25 2008

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