JMS/Sandbox/msn2
From Proteopedia
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<text>Highlight 9aaTAD Transactivation Motif (261-269)</text> | <text>Highlight 9aaTAD Transactivation Motif (261-269)</text> | ||
</jmolLink></jmol>) | </jmolLink></jmol>) | ||
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Explanation: Selects the 9aaTAD motif (residues 261-269 ). Colors it yellow and displays it as a trace (smoothed backbone representation) for clarity within potentially disordered regions. The selection blinks, and the view centers/zooms. | Explanation: Selects the 9aaTAD motif (residues 261-269 ). Colors it yellow and displays it as a trace (smoothed backbone representation) for clarity within potentially disordered regions. The selection blinks, and the view centers/zooms. | ||
4.6. Highlight Key PKA Phosphorylation Sites (S288, S582, S620, S625, S633) | 4.6. Highlight Key PKA Phosphorylation Sites (S288, S582, S620, S625, S633) | ||
Focuses specifically on the sidechains of the key PKA sites regulating Msn2 localization. | Focuses specifically on the sidechains of the key PKA sites regulating Msn2 localization. | ||
Code snippet | Code snippet | ||
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The precise interaction with DNA likely involves specific residues within these fingers making contact with the STRE sequence. | The precise interaction with DNA likely involves specific residues within these fingers making contact with the STRE sequence. | ||
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</script> | </script> | ||
<text>Highlight Predicted Disordered Regions (84-246, 418-437, 592-634)</text> | <text>Highlight Predicted Disordered Regions (84-246, 418-437, 592-634)</text> | ||
| + | </jmolLink></jmol>) | ||
| + | |||
(<jmol><jmolLink> | (<jmol><jmolLink> | ||
<script> | <script> | ||
Revision as of 13:50, 5 May 2025
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Zinc Fingers
Msn2 binds DNA via two C2H2 zinc finger domains located in the C-terminal region (residues 647-665 and 676-698).[4] These domains recognize the Stress Response Element (STRE) in the promoters of target genes.[1, 45] The AlphaFold model predicts these domains with high confidence (blue regions in the default view). Click the link to highlight these domains and the coordinating Zinc ions.
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Explanation: Selects the 9aaTAD motif (residues 261-269 ). Colors it yellow and displays it as a trace (smoothed backbone representation) for clarity within potentially disordered regions. The selection blinks, and the view centers/zooms. 4.6. Highlight Key PKA Phosphorylation Sites (S288, S582, S620, S625, S633) Focuses specifically on the sidechains of the key PKA sites regulating Msn2 localization. Code snippet
The precise interaction with DNA likely involves specific residues within these fingers making contact with the STRE sequence.
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