JMS/Sandbox/msn2
From Proteopedia
(Difference between revisions)
(Replacing page with '# Msn2 (P33748): Interactive Structure of a Yeast Stress-Responsive Transcription Factor <applet load='AF-P33748-F1-model v4.pdb' size='400' frame='true' align='right' caption...') |
|||
| Line 2: | Line 2: | ||
<applet load='AF-P33748-F1-model v4.pdb' size='400' frame='true' align='right' caption='' scene='10/1080095/Msn2/1'/>__NOTOC__ | <applet load='AF-P33748-F1-model v4.pdb' size='400' frame='true' align='right' caption='' scene='10/1080095/Msn2/1'/>__NOTOC__ | ||
| + | |||
| + | === Zinc Fingers === | ||
| + | |||
| + | Msn2 binds DNA via two C2H2 zinc finger domains located in the C-terminal region (residues 647-665 and 676-698).[4] These domains recognize the Stress Response Element (STRE) in the promoters of target genes.[1, 45] The AlphaFold model predicts these domains with high confidence (blue regions in the default view). Click the link to highlight these domains and the coordinating Zinc ions. | ||
| + | |||
| + | |||
| + | |||
| + | (<jmol><jmolLink> | ||
| + | |||
| + | <script> | ||
| + | |||
| + | select 647-665, 676-698; color magenta; backbone 0.7; wireframe 0.15; | ||
| + | |||
| + | select zn; spacefill 1.2; color cpk; | ||
| + | |||
| + | selectionHalos ON; delay 1.5; selectionHalos OFF; | ||
| + | |||
| + | center selected; zoom 150; | ||
| + | |||
| + | </script> | ||
| + | |||
| + | <text>Highlight Zinc Fingers (DNA Binding: 647-665, 676-698)</text> | ||
| + | |||
| + | </jmolLink></jmol>) | ||
Revision as of 14:14, 5 May 2025
- Msn2 (P33748): Interactive Structure of a Yeast Stress-Responsive Transcription Factor
|
Zinc Fingers
Msn2 binds DNA via two C2H2 zinc finger domains located in the C-terminal region (residues 647-665 and 676-698).[4] These domains recognize the Stress Response Element (STRE) in the promoters of target genes.[1, 45] The AlphaFold model predicts these domains with high confidence (blue regions in the default view). Click the link to highlight these domains and the coordinating Zinc ions.
()
