9nyy
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Nucleic acid bound human SLFN14, State 1== | |
| - | + | <StructureSection load='9nyy' size='340' side='right'caption='[[9nyy]], [[Resolution|resolution]] 2.73Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9nyy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NYY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NYY FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.73Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9nyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9nyy OCA], [https://pdbe.org/9nyy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9nyy RCSB], [https://www.ebi.ac.uk/pdbsum/9nyy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9nyy ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/SLN14_HUMAN SLN14_HUMAN] Autosomal dominant thrombocytopenia with platelet secretion defect. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SLN14_HUMAN SLN14_HUMAN] Shows no ribosome-associated and endoribonuclease activities.<ref>PMID:25996083</ref> Displays polysome-associated endoribonuclease activity towards mRNAs and rRNAs (PubMed:25996083). May play a role in RNA surveillance pathways by recognizing stalled ribosomes and triggering endonucleolytic cleavage of aberrant mRNAs (Probable). Cleaves different types of rRNAs and mRNAs in a magnesium- and manganese-dependent and ATP-independent manner (By similarity). Involved in correct maturation of megakaryocytes and especially important for proplatelet extension.[UniProtKB:G1SRW8]<ref>PMID:25996083</ref> <ref>PMID:26769223</ref> <ref>PMID:25996083</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Maheshwari S]] | ||
| + | [[Category: Martinez-Claros AO]] | ||
| + | [[Category: Pillon MC]] | ||
| + | [[Category: Schneiderman H]] | ||
| + | [[Category: Van Riper J]] | ||
| + | [[Category: Wang L]] | ||
Current revision
Nucleic acid bound human SLFN14, State 1
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