9od5
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of the Ebola Transcriptional Regulatory Signal - configuration A== | |
| + | <StructureSection load='9od5' size='340' side='right'caption='[[9od5]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[9od5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ebola_virus Ebola virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9OD5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9OD5 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9od5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9od5 OCA], [https://pdbe.org/9od5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9od5 RCSB], [https://www.ebi.ac.uk/pdbsum/9od5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9od5 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The transcription of ebolavirus (EBOV) genomes is a major checkpoint in the viral life cycle. Altering the transcription regulatory signal (TRS), an RNA hairpin that forms in the 3' leader sequence of EBOV, affects transcription in a VP30-dependent manner. How this mechanistically occurs is currently unknown. Here, we find that the TRS primarily equilibrates between two structures that differ in their loops. Mutational studies demonstrate that the entire hairpin structure is important in directing both VP30 binding and regulating EBOV transcriptional activity, with the loop being the principal structural element. In doing so, we highlight that the TRS structure is a critical determinant of EBOV transcription. | ||
| - | + | The Ebolavirus Transcription Regulatory Signal Equilibrates Between Two Structural Conformations to Affect VP30 Binding.,Edwards JM, Kachale A, McCleery SR, Law GA, Patel V, D'Souza VM, Pham VV J Mol Biol. 2025 Sep 25;437(24):169464. doi: 10.1016/j.jmb.2025.169464. PMID:41015113<ref>PMID:41015113</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 9od5" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ebola virus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Edwards JM]] | ||
| + | [[Category: Kachale A]] | ||
| + | [[Category: Pham VV]] | ||
Current revision
Solution structure of the Ebola Transcriptional Regulatory Signal - configuration A
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