1vs3

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{{STRUCTURE_1vs3| PDB=1vs3 | SCENE= }}
{{STRUCTURE_1vs3| PDB=1vs3 | SCENE= }}
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'''Crystal Structure of the tRNA Pseudouridine Synthase TruA From Thermus thermophilus HB8'''
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===Crystal Structure of the tRNA Pseudouridine Synthase TruA From Thermus thermophilus HB8===
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==Overview==
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The pseudouridine synthase (Psi synthase) TruA catalyzes the conversion of uridine to pseudouridine at positions 38, 39 and/or 40 in the anticodon stem-loop (ASL) of tRNA. We have determined the crystal structure of TruA from Thermus thermophilus HB8 at 2.25 A resolution. TruA and the other (Psi synthases have a completely conserved active site aspartate, which suggests that the members of this enzyme family share a common catalytic mechanism. The T. thermophilus TruA structure reveals the remarkably flexible structural features in the tRNA-binding cleft, which may be responsible for the primary tRNA interaction. In addition, the charged residues occupying the intermediate positions in the cleft may lead the tRNA to the active site for catalysis. Based on the TruB-tRNA complex structure, the T. thermophilus TruA structure reveals that the tRNA probably makes the melting base pairs move into the cleft, and suggests that a conformational change of the substrate tRNA is necessary to facilitate access to the active site aspartate residue, deep within the cleft.
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{{ABSTRACT_PUBMED_17114947}}
==About this Structure==
==About this Structure==
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[[Category: Trna modification]]
[[Category: Trna modification]]
[[Category: Trua]]
[[Category: Trua]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:51:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:12:53 2008''

Revision as of 11:12, 29 July 2008

Image:1vs3.png

Template:STRUCTURE 1vs3

Crystal Structure of the tRNA Pseudouridine Synthase TruA From Thermus thermophilus HB8

Template:ABSTRACT PUBMED 17114947

About this Structure

1VS3 is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Crystal structure of tRNA pseudouridine synthase TruA from Thermus thermophilus HB8., Dong X, Bessho Y, Shibata R, Nishimoto M, Shirouzu M, Kuramitsu S, Yokoyama S, RNA Biol. 2006 Jul;3(3):115-22. Epub 2006 Jul 17. PMID:17114947

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