9o9u

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Current revision (09:19, 22 October 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9o9u is ON HOLD until Paper Publication
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==The Erlin1/2 complex==
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<StructureSection load='9o9u' size='340' side='right'caption='[[9o9u]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9o9u]] is a 26 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9O9U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9O9U FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9o9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9o9u OCA], [https://pdbe.org/9o9u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9o9u RCSB], [https://www.ebi.ac.uk/pdbsum/9o9u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9o9u ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ERLN1_HUMAN ERLN1_HUMAN] Autosomal recessive spastic paraplegia type 62. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/ERLN1_HUMAN ERLN1_HUMAN] Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway (PubMed:37683630). Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (PubMed:24217618).<ref>PMID:19240031</ref> <ref>PMID:24217618</ref> <ref>PMID:37683630</ref> (Microbial infection) Required early in hepatitis C virus (HCV) infection to initiate RNA replication, and later in the infection to support infectious virus production.<ref>PMID:31810281</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Gao J]]
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[[Category: Shao S]]

Current revision

The Erlin1/2 complex

PDB ID 9o9u

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