1vyh

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{{STRUCTURE_1vyh| PDB=1vyh | SCENE= }}
{{STRUCTURE_1vyh| PDB=1vyh | SCENE= }}
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'''PAF-AH HOLOENZYME: LIS1/ALFA2'''
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===PAF-AH HOLOENZYME: LIS1/ALFA2===
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==Overview==
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Mutations in the LIS1 gene cause lissencephaly, a human neuronal migration disorder. LIS1 binds dynein and the dynein-associated proteins Nde1 (formerly known as NudE), Ndel1 (formerly known as NUDEL), and CLIP-170, as well as the catalytic alpha dimers of brain cytosolic platelet activating factor acetylhydrolase (PAF-AH). The mechanism coupling the two diverse regulatory pathways remains unknown. We report the structure of LIS1 in complex with the alpha2/alpha2 PAF-AH homodimer. One LIS1 homodimer binds symmetrically to one alpha2/alpha2 homodimer via the highly conserved top faces of the LIS1 beta propellers. The same surface of LIS1 contains sites of mutations causing lissencephaly and overlaps with a putative dynein binding surface. Ndel1 competes with the alpha2/alpha2 homodimer for LIS1, but the interaction is complex and requires both the N- and C-terminal domains of LIS1. Our data suggest that the LIS1 molecule undergoes major conformational rearrangement when switching from a complex with the acetylhydrolase to the one with Ndel1.
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{{ABSTRACT_PUBMED_15572112}}
==About this Structure==
==About this Structure==
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[[Category: Platelet activacting factor]]
[[Category: Platelet activacting factor]]
[[Category: Regulator of cytoplasmic dynein]]
[[Category: Regulator of cytoplasmic dynein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:01:37 2008''

Revision as of 01:01, 28 July 2008

Image:1vyh.png

Template:STRUCTURE 1vyh

PAF-AH HOLOENZYME: LIS1/ALFA2

Template:ABSTRACT PUBMED 15572112

About this Structure

1VYH is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase., Tarricone C, Perrina F, Monzani S, Massimiliano L, Kim MH, Derewenda ZS, Knapp S, Tsai LH, Musacchio A, Neuron. 2004 Dec 2;44(5):809-21. PMID:15572112

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