9v0k

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m (Protected "9v0k" [edit=sysop:move=sysop])
Current revision (08:41, 4 June 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9v0k is ON HOLD
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==UBR box of human UBR1==
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<StructureSection load='9v0k' size='340' side='right'caption='[[9v0k]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
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Authors: Lee, S., Song, H.K.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9v0k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9V0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9V0K FirstGlance]. <br>
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Description: UBR box of human UBR1
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.54&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Lee, S]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9v0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9v0k OCA], [https://pdbe.org/9v0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9v0k RCSB], [https://www.ebi.ac.uk/pdbsum/9v0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9v0k ProSAT]</span></td></tr>
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[[Category: Song, H.K]]
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/UBR1_HUMAN UBR1_HUMAN] Johanson-Blizzard syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/UBR1_HUMAN UBR1_HUMAN] E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.<ref>PMID:15548684</ref> <ref>PMID:16311597</ref> <ref>PMID:20298436</ref> <ref>PMID:20835242</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Lee S]]
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[[Category: Song HK]]

Current revision

UBR box of human UBR1

PDB ID 9v0k

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