1vzh

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[[Image:1vzh.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1vzh| PDB=1vzh | SCENE= }}
{{STRUCTURE_1vzh| PDB=1vzh | SCENE= }}
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'''STRUCTURE OF SUPEROXIDE REDUCTASE BOUND TO FERROCYANIDE AND ACTIVE SITE EXPANSION UPON X-RAY INDUCED PHOTOREDUCTION'''
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===STRUCTURE OF SUPEROXIDE REDUCTASE BOUND TO FERROCYANIDE AND ACTIVE SITE EXPANSION UPON X-RAY INDUCED PHOTOREDUCTION===
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==Overview==
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Some sulfate-reducing and microaerophilic bacteria rely on the enzyme superoxide reductase (SOR) to eliminate the toxic superoxide anion radical (O2*-). SOR catalyses the one-electron reduction of O2*- to hydrogen peroxide at a nonheme ferrous iron center. The structures of Desulfoarculus baarsii SOR (mutant E47A) alone and in complex with ferrocyanide were solved to 1.15 and 1.7 A resolution, respectively. The latter structure, the first ever reported of a complex between ferrocyanide and a protein, reveals that this organo-metallic compound entirely plugs the SOR active site, coordinating the active iron through a bent cyano bridge. The subtle structural differences between the mixed-valence and the fully reduced SOR-ferrocyanide adducts were investigated by taking advantage of the photoelectrons induced by X-rays. The results reveal that photo-reduction from Fe(III) to Fe(II) of the iron center, a very rapid process under a powerful synchrotron beam, induces an expansion of the SOR active site.
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(as it appears on PubMed at http://www.pubmed.gov), where 15341736 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15341736}}
==About this Structure==
==About this Structure==
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[[Category: Photoreduction]]
[[Category: Photoreduction]]
[[Category: Redox state]]
[[Category: Redox state]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:57:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:46:03 2008''

Revision as of 05:46, 28 July 2008

Image:1vzh.png

Template:STRUCTURE 1vzh

STRUCTURE OF SUPEROXIDE REDUCTASE BOUND TO FERROCYANIDE AND ACTIVE SITE EXPANSION UPON X-RAY INDUCED PHOTOREDUCTION

Template:ABSTRACT PUBMED 15341736

About this Structure

1VZH is a Single protein structure of sequence from Desulfovibrio baarsii. Full crystallographic information is available from OCA.

Reference

Structure of superoxide reductase bound to ferrocyanide and active site expansion upon X-ray-induced photo-reduction., Adam V, Royant A, Niviere V, Molina-Heredia FP, Bourgeois D, Structure. 2004 Sep;12(9):1729-40. PMID:15341736

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