1vzw

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[[Image:1vzw.gif|left|200px]]
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{{Seed}}
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[[Image:1vzw.png|left|200px]]
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{{STRUCTURE_1vzw| PDB=1vzw | SCENE= }}
{{STRUCTURE_1vzw| PDB=1vzw | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE BIFUNCTIONAL PROTEIN PRIA'''
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===CRYSTAL STRUCTURE OF THE BIFUNCTIONAL PROTEIN PRIA===
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==Overview==
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Some bacterial genomes contain an incomplete set of genes encoding phosphoribosyl isomerases, raising the question of whether there exists broadened substrate specificity for the missing gene products. To investigate the underlying molecular principles of this hypothesis, we have determined the crystal structure of the bifunctional enzyme PriA from Streptomyces coelicolor at 1.8 A resolution. It consists of a (betaalpha)(8)-barrel fold that is assembled by two symmetric (betaalpha)(4) half-barrels. The structure shows how its active site may catalyse the isomerization reactions of two different substrates, and we provide a plausible model of how the smaller of the two substrates could be bound in two different orientations. Our findings expand the half-barrel ancestor concept by demonstrating that symmetry-related half-barrels could provide a smart solution to cope with dual substrate specificity. The data may help to unravel molecular rationales regarding how organisms with miniature genomes can keep central biological pathways functional.
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The line below this paragraph, {{ABSTRACT_PUBMED_15654319}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15654319 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15654319}}
==About this Structure==
==About this Structure==
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[[Category: Isomerase]]
[[Category: Isomerase]]
[[Category: Tryptophan biosynthesis]]
[[Category: Tryptophan biosynthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:58:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:47:35 2008''

Revision as of 21:47, 27 July 2008

Image:1vzw.png

Template:STRUCTURE 1vzw

CRYSTAL STRUCTURE OF THE BIFUNCTIONAL PROTEIN PRIA

Template:ABSTRACT PUBMED 15654319

About this Structure

1VZW is a Single protein structure of sequence from Streptomyces coelicolor. Full crystallographic information is available from OCA.

Reference

Two-fold repeated (betaalpha)4 half-barrels may provide a molecular tool for dual substrate specificity., Kuper J, Doenges C, Wilmanns M, EMBO Rep. 2005 Feb;6(2):134-9. PMID:15654319

Page seeded by OCA on Mon Jul 28 00:47:35 2008

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