1vzy

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{{STRUCTURE_1vzy| PDB=1vzy | SCENE= }}
{{STRUCTURE_1vzy| PDB=1vzy | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE BACILLUS SUBTILIS HSP33'''
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===CRYSTAL STRUCTURE OF THE BACILLUS SUBTILIS HSP33===
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==Overview==
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The bacterial heat shock protein Hsp33 is a redox-regulated chaperone activated by oxidative stress. In response to oxidation, four cysteines within a Zn2+ binding C-terminal domain form two disulfide bonds with concomitant release of the metal. This leads to the formation of the biologically active Hsp33 dimer. The crystal structure of the N-terminal domain of the E. coli protein has been reported, but neither the structure of the Zn2+ binding motif nor the nature of its regulatory interaction with the rest of the protein are known. Here we report the crystal structure of the full-length B. subtilis Hsp33 in the reduced form. The structure of the N-terminal, dimerization domain is similar to that of the E. coli protein, although there is no domain swapping. The Zn2+ binding domain is clearly resolved showing the details of the tetrahedral coordination of Zn2+ by four thiolates. We propose a structure-based activation pathway for Hsp33.
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(as it appears on PubMed at http://www.pubmed.gov), where 15458638 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15458638}}
==About this Structure==
==About this Structure==
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
[[Category: MCSG, Midwest Center for Structural Genomics.]]
[[Category: Heat shock protein,crystal engineering,molecular chaperone,redox-active center,psi,protein structure initiative,mcsg,midwest center for structural genomic]]
[[Category: Heat shock protein,crystal engineering,molecular chaperone,redox-active center,psi,protein structure initiative,mcsg,midwest center for structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:58:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:54:42 2008''

Revision as of 11:54, 27 July 2008

Image:1vzy.png

Template:STRUCTURE 1vzy

CRYSTAL STRUCTURE OF THE BACILLUS SUBTILIS HSP33

Template:ABSTRACT PUBMED 15458638

About this Structure

1VZY is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

The crystal structure of the reduced, Zn2+-bound form of the B. subtilis Hsp33 chaperone and its implications for the activation mechanism., Janda I, Devedjiev Y, Derewenda U, Dauter Z, Bielnicki J, Cooper DR, Graf PC, Joachimiak A, Jakob U, Derewenda ZS, Structure. 2004 Oct;12(10):1901-7. PMID:15458638

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