1w0k

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{{STRUCTURE_1w0k| PDB=1w0k | SCENE= }}
{{STRUCTURE_1w0k| PDB=1w0k | SCENE= }}
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'''BERYLLIUM FLUORIDE INHIBITED BOVINE F1-ATPASE'''
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===BERYLLIUM FLUORIDE INHIBITED BOVINE F1-ATPASE===
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==Overview==
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The structure of bovine F1-ATPase inhibited with ADP and beryllium fluoride at 2.0 angstroms resolution contains two ADP.BeF3- complexes mimicking ATP, bound in the catalytic sites of the beta(TP) and beta(DP) subunits. Except for a 1 angstrom shift in the guanidinium of alphaArg373, the conformations of catalytic side chains are very similar in both sites. However, the ordered water molecule that carries out nucleophilic attack on the gamma-phosphate of ATP during hydrolysis is 2.6 angstroms from the beryllium in the beta(DP) subunit and 3.8 angstroms away in the beta(TP) subunit, strongly indicating that the beta(DP) subunit is the catalytically active conformation. In the structure of F1-ATPase with five bound ADP molecules (three in alpha-subunits, one each in the beta(TP) and beta(DP) subunits), which has also been determined, the conformation of alphaArg373 suggests that it senses the presence (or absence) of the gamma-phosphate of ATP. Two catalytic schemes are discussed concerning the various structures of bovine F1-ATPase.
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(as it appears on PubMed at http://www.pubmed.gov), where 15229653 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15229653}}
==About this Structure==
==About this Structure==
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[[Category: F1fo atp synthase]]
[[Category: F1fo atp synthase]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:59:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:33:41 2008''

Revision as of 23:33, 28 July 2008

Image:1w0k.png

Template:STRUCTURE 1w0k

BERYLLIUM FLUORIDE INHIBITED BOVINE F1-ATPASE

Template:ABSTRACT PUBMED 15229653

About this Structure

1W0K is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

The structure of bovine F1-ATPase inhibited by ADP and beryllium fluoride., Kagawa R, Montgomery MG, Braig K, Leslie AG, Walker JE, EMBO J. 2004 Jul 21;23(14):2734-44. Epub 2004 Jul 1. PMID:15229653

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