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1w0y

From Proteopedia

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[[Image:1w0y.gif|left|200px]]
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{{Seed}}
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[[Image:1w0y.png|left|200px]]
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{{STRUCTURE_1w0y| PDB=1w0y | SCENE= }}
{{STRUCTURE_1w0y| PDB=1w0y | SCENE= }}
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'''TF7A_3771 COMPLEX'''
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===TF7A_3771 COMPLEX===
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==Overview==
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Proof of concept experiments have shown that tissue factor/factor VIIa inhibitors have antithrombotic activity without enhancing bleeding propensity. Starting from lead compounds generated by a biased combinatorial approach, phenylglycine amide tissue factor/factor VIIa inhibitors with low nanomolar affinity and good selectivity against other serine proteases of the coagulation cascade were designed, using the guidance of X-ray structural analysis and molecular modelling.
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The line below this paragraph, {{ABSTRACT_PUBMED_15664864}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15664864 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15664864}}
==About this Structure==
==About this Structure==
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[[Category: Serine protease]]
[[Category: Serine protease]]
[[Category: Vitamin k]]
[[Category: Vitamin k]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:00:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:10:12 2008''

Revision as of 19:10, 28 July 2008

Image:1w0y.png

Template:STRUCTURE 1w0y

TF7A_3771 COMPLEX

Template:ABSTRACT PUBMED 15664864

About this Structure

1W0Y is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors., Groebke Zbinden K, Banner DW, Ackermann J, D'Arcy A, Kirchhofer D, Ji YH, Tschopp TB, Wallbaum S, Weber L, Bioorg Med Chem Lett. 2005 Feb 1;15(3):817-22. PMID:15664864

Page seeded by OCA on Mon Jul 28 22:10:12 2008

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OCA

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