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Revision as of 18:03, 8 June 2025

ACE2 (angiotensin-converting enzyme 2)

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image (TRADUZIR)A enzima conversora de angiotensina 2 (ACE2) é uma importante enzima do sistema renina-angiotensina-aldosterona (SRAA). Ela pode ser encontrada em diversos tecidos, seja ancorada à membrana celular (mACE2), como uma proteína transmembrana, ou em uma forma solúvel, chamada sACE2. Outra função da enzima conversora de angiotensina 2 é servir como receptor para alguns vírus, incluindo o SARS-CoV-2, responsável pela pandemia de COVID-19 em 2020. Essa ligação ao receptor e a entrada na célula ocorrem pela ligação da subunidade S1 da proteína Spike (S) do vírus à ACE2. [3] You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue. Protein ACE2, 1r42 Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights 4.1 ACE2 4.2 Complexo ACE2-B0AT1 Function Disease Relevance Structural highlights ACE2 This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. Complexo ACE2-B0AT1

References

1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644

3. Beyerstedt S, Casaro EB, Rangel ÉB. COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection. Eur J Clin Microbiol Infect Dis. 2021 May;40(5):905-919. doi: 10.1007/s10096-020-04138-6. Epub 2021 Jan 3. PMID: 33389262; PMCID: PMC7778857.

4. Towler P, Staker B, Prasad SG, Menon S, Tang J, Parsons T, Ryan D, Fisher M, Williams D, Dales NA, Patane MA, Pantoliano MW. ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis. J Biol Chem. 2004 Apr 23;279(17):17996-8007. doi: 10.1074/jbc.M311191200. Epub 2004 Jan 30. PMID: 14754895; PMCID: PMC7980034.