9gcn

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Current revision (05:34, 6 August 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9gcn is ON HOLD until Paper Publication
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==Co-crystal VHH (TPL1158_01_C09) - alpha-cobratoxin (Naja kaouthia)==
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<StructureSection load='9gcn' size='340' side='right'caption='[[9gcn]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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Authors: Rivera-de-Torre, E., Burlet, N.J., Laustsen, A.H., Morth, J.P.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9gcn]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia] and [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GCN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GCN FirstGlance]. <br>
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Description: Co-crystal VHH (TPL1158_01_C09) -alpha-cobratoxin (Naja kaouthia)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gcn OCA], [https://pdbe.org/9gcn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gcn RCSB], [https://www.ebi.ac.uk/pdbsum/9gcn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gcn ProSAT]</span></td></tr>
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[[Category: Laustsen, A.H]]
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</table>
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[[Category: Morth, J.P]]
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== Function ==
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[[Category: Burlet, N.J]]
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[https://www.uniprot.org/uniprot/3L21_NAJKA 3L21_NAJKA] Monomer: binds with high affinity to muscular (alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND) nAChR (tested on Torpedo californica, Kd=0.2-4.5 nM) and neuronal alpha-7/CHRNA7 nicotinic acetylcholine receptors (Kd=13-105 nM) (PubMed:18381281, PubMed:22223648, PubMed:9305882). Also inhibits GABA(A) channels (PubMed:26221036). Heteropentamer targets studied are composed of alpha-1-beta-3-gamma-2 (GABRA1-GABRB3-GABRG2) subunits (IC(50)=236 nM), alpha-1-beta-2-gamma-2 (GABRA1-GABRB2-GABRG2) subunits (IC(50)=469 nM), alpha-2-beta-2-gamma-2 (GABRA2-GABRB2-GABRG2) subunits (IC(50)=485 nM), alpha-5-beta-3-gamma-2 (GABRA5-GABRB3-GABRG2) subunits (IC(50)=635 nM), and alpha-2-beta-3-gamma-2 (GABRA2-GABRB3-GABRG2) subunits (IC(50)=1099 nM) (activated by 10 uM GABA) (PubMed:26221036).<ref>PMID:18381281</ref> <ref>PMID:22223648</ref> <ref>PMID:26221036</ref> <ref>PMID:30025921</ref> Homodimer: binds with high affinity (but lower than the monomeric form) to muscular (IC(50)=9.7 nM) and with low affinity to neuronal alpha-7/CHRNA7 nAChRs (IC(50)=1370 nM) (PubMed:22223648). However, it acquires (compared to the monomeric form) the capacity to block alpha-3/beta-2 (CHRNA3/CHRNB2) nAChRs (PubMed:18381281).<ref>PMID:18381281</ref> <ref>PMID:22223648</ref> Heterodimer with cytotoxin 3 (AC P01446): is slightly more active than the homodimer in inhibiting alpha-7/CHRNA7 nAChR and is considerably more active in blocking the alpha-3-beta-2/CHRNA3-CHRNB2 nAChR.<ref>PMID:22223648</ref>
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[[Category: Rivera-De-Torre, E]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Naja kaouthia]]
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[[Category: Vicugna pacos]]
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[[Category: Burlet NJ]]
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[[Category: Laustsen AH]]
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[[Category: Morth JP]]
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[[Category: Rivera-de-Torre E]]

Current revision

Co-crystal VHH (TPL1158_01_C09) - alpha-cobratoxin (Naja kaouthia)

PDB ID 9gcn

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