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1w1w

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[[Image:1w1w.gif|left|200px]]
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[[Image:1w1w.png|left|200px]]
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{{STRUCTURE_1w1w| PDB=1w1w | SCENE= }}
{{STRUCTURE_1w1w| PDB=1w1w | SCENE= }}
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'''SC SMC1HD:SCC1-C COMPLEX, ATPGS'''
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===SC SMC1HD:SCC1-C COMPLEX, ATPGS===
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==Overview==
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A multisubunit complex called cohesin forms a huge ring structure that mediates sister chromatid cohesion, possibly by entrapping sister DNAs following replication. Cohesin's kleisin subunit Scc1 completes the ring, connecting the ABC-like ATPase heads of a V-shaped Smc1/3 heterodimer. Proteolytic cleavage of Scc1 by separase triggers sister chromatid disjunction, presumably by breaking the Scc1 bridge. One half of the SMC-kleisin bridge is revealed here by a crystal structure of Smc1's ATPase complexed with Scc1's C-terminal domain. The latter forms a winged helix that binds a pair of beta strands in Smc1's ATPase head. Mutation of conserved residues within the contact interface destroys Scc1's interaction with Smc1/3 heterodimers and eliminates cohesin function. Interaction of Scc1's N terminus with Smc3 depends on prior C terminus connection with Smc1. There is little or no turnover of Smc1-Scc1 interactions within cohesin complexes in vivo because expression of noncleavable Scc1 after DNA replication does not hinder anaphase.
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(as it appears on PubMed at http://www.pubmed.gov), where 15383284 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15383284}}
==About this Structure==
==About this Structure==
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[[Category: Kleisin]]
[[Category: Kleisin]]
[[Category: Mitosis]]
[[Category: Mitosis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:02:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:04:53 2008''

Revision as of 12:04, 28 July 2008

Image:1w1w.png

Template:STRUCTURE 1w1w

SC SMC1HD:SCC1-C COMPLEX, ATPGS

Template:ABSTRACT PUBMED 15383284

About this Structure

1W1W is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure and stability of cohesin's Smc1-kleisin interaction., Haering CH, Schoffnegger D, Nishino T, Helmhart W, Nasmyth K, Lowe J, Mol Cell. 2004 Sep 24;15(6):951-64. PMID:15383284

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