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1w3c

From Proteopedia

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[[Image:1w3c.gif|left|200px]]
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{{STRUCTURE_1w3c| PDB=1w3c | SCENE= }}
{{STRUCTURE_1w3c| PDB=1w3c | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS3 PROTEASE IN COMPLEX WITH A PEPTIDOMIMETIC INHIBITOR'''
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===CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS3 PROTEASE IN COMPLEX WITH A PEPTIDOMIMETIC INHIBITOR===
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==Overview==
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The design of a series of peptidomimetic inhibitors of the hepatitis C virus NS3 protease is described. These inhibitors feature an indoline-2-carboxamide as a novel heterocyclic replacement for the P3 amino acid residue and N-terminal capping group of tripeptide based inhibitors. The crystal structure of the ternary NS3/NS4A/inhibitor complex for the most active molecule in this series highlights its suitability as an N-terminal capping group of a dipeptide inhibitor of the NS3 protease.
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(as it appears on PubMed at http://www.pubmed.gov), where 15588076 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15588076}}
==About this Structure==
==About this Structure==
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[[Category: Indoline-based peptidomimetic inhibito]]
[[Category: Indoline-based peptidomimetic inhibito]]
[[Category: Serine protease]]
[[Category: Serine protease]]
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Revision as of 05:22, 29 July 2008

Image:1w3c.png

Template:STRUCTURE 1w3c

CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS3 PROTEASE IN COMPLEX WITH A PEPTIDOMIMETIC INHIBITOR

Template:ABSTRACT PUBMED 15588076

About this Structure

1W3C is a Single protein structure of sequence from Viruses. Full crystallographic information is available from OCA.

Reference

The design and enzyme-bound crystal structure of indoline based peptidomimetic inhibitors of hepatitis C virus NS3 protease., Ontoria JM, Di Marco S, Conte I, Di Francesco ME, Gardelli C, Koch U, Matassa VG, Poma M, Steinkuhler C, Volpari C, Harper S, J Med Chem. 2004 Dec 16;47(26):6443-6. PMID:15588076

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