1w45

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{{STRUCTURE_1w45| PDB=1w45 | SCENE= }}
{{STRUCTURE_1w45| PDB=1w45 | SCENE= }}
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'''THE 2.5 ANGSTROEM STRUCTURE OF THE K16A MUTANT OF ANNEXIN A8, WHICH HAS AN INTACT N-TERMINUS.'''
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===THE 2.5 ANGSTROEM STRUCTURE OF THE K16A MUTANT OF ANNEXIN A8, WHICH HAS AN INTACT N-TERMINUS.===
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==Overview==
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Annexin A8 is a relatively infrequent and poorly studied member of this large family of calcium-binding and membrane-binding proteins. It is, however, associated with a specific disease, acute promyelocytic leukemia. We have solved its three-dimensional structure, which includes a moderately long and intact N terminus. The structure is closest to that of annexin A3 and highlights several important regions of inherent flexibility in the annexin molecule. The N terminus resembles that of annexin A3, as it lies along the concave surface of the molecule and inserts partially into the hydrophilic channel in its centre. Since both annexins A3 and A8 are expressed in promyelocytic cells during their differentiation, the similarity in their structures might suggest a functional relationship.
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(as it appears on PubMed at http://www.pubmed.gov), where 15644210 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15644210}}
==About this Structure==
==About this Structure==
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[[Category: Cxalcium and membrane-binding protein]]
[[Category: Cxalcium and membrane-binding protein]]
[[Category: Intact n-terminus]]
[[Category: Intact n-terminus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:07:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:41:51 2008''

Revision as of 01:41, 29 July 2008

Image:1w45.png

Template:STRUCTURE 1w45

THE 2.5 ANGSTROEM STRUCTURE OF THE K16A MUTANT OF ANNEXIN A8, WHICH HAS AN INTACT N-TERMINUS.

Template:ABSTRACT PUBMED 15644210

About this Structure

1W45 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of annexin A8 is similar to that of annexin A3., Rety S, Sopkova-de Oliveira Santos J, Dreyfuss L, Blondeau K, Hofbauerova K, Raguenes-Nicol C, Kerboeuf D, Renouard M, Russo-Marie F, Lewit-Bentley A, J Mol Biol. 2005 Feb 4;345(5):1131-9. Epub 2004 Dec 8. PMID:15644210

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