1w51

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{{STRUCTURE_1w51| PDB=1w51 | SCENE= }}
{{STRUCTURE_1w51| PDB=1w51 | SCENE= }}
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'''BACE (BETA SECRETASE) IN COMPLEX WITH A NANOMOLAR NON-PEPTIDIC INHIBITOR'''
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===BACE (BETA SECRETASE) IN COMPLEX WITH A NANOMOLAR NON-PEPTIDIC INHIBITOR===
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==Overview==
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Human BACE, also known as beta-secretase, shows promise as a potential therapeutic target for Alzheimer's disease. We determined the apo structure of BACE to 1.75 A, and a structure of a hydroxyethylamine inhibitor complex derived by soaking. These show significant active-site movements compared to previously described BACE structures. Additionally, the structures reveal two pockets that could be targeted by structure-based drug design.
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(as it appears on PubMed at http://www.pubmed.gov), where 15451669 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15451669}}
==About this Structure==
==About this Structure==
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[[Category: Transmembrane]]
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[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:10:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:02:15 2008''

Revision as of 17:02, 27 July 2008

Image:1w51.png

Template:STRUCTURE 1w51

BACE (BETA SECRETASE) IN COMPLEX WITH A NANOMOLAR NON-PEPTIDIC INHIBITOR

Template:ABSTRACT PUBMED 15451669

About this Structure

1W51 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Apo and inhibitor complex structures of BACE (beta-secretase)., Patel S, Vuillard L, Cleasby A, Murray CW, Yon J, J Mol Biol. 2004 Oct 15;343(2):407-16. PMID:15451669

Page seeded by OCA on Sun Jul 27 20:02:15 2008

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