1w78

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{{STRUCTURE_1w78| PDB=1w78 | SCENE= }}
{{STRUCTURE_1w78| PDB=1w78 | SCENE= }}
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'''E.COLI FOLC IN COMPLEX WITH DHPP AND ADP'''
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===E.COLI FOLC IN COMPLEX WITH DHPP AND ADP===
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==Overview==
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In some bacteria, such as Escherichia coli, the addition of L-glutamate to dihydropteroate (dihydrofolate synthetase activity) and the subsequent additions of L-glutamate to tetrahydrofolate (folylpolyglutamate synthetase (FPGS) activity) are catalyzed by the same enzyme, FolC. The crystal structure of E. coli FolC is described in this paper. It showed strong similarities to that of the FPGS enzyme of Lactobacillus casei within the ATP binding site and the catalytic site, as do all other members of the Mur synthethase superfamily. FolC structure revealed an unexpected dihydropteroate binding site very different from the folate site identified previously in the FPGS structure. The relevance of this site is exemplified by the presence of phosphorylated dihydropteroate, a reaction intermediate in the DHFS reaction. L. casei FPGS is considered a relevant model for human FPGS. As such, the presence of a folate binding site in E. coli FolC, which is different from the one seen in FPGS enzymes, provides avenues for the design of specific inhibitors of this enzyme in antimicrobial therapy.
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{{ABSTRACT_PUBMED_15705579}}
==About this Structure==
==About this Structure==
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[[Category: Multifunctional enzyme]]
[[Category: Multifunctional enzyme]]
[[Category: Synthase]]
[[Category: Synthase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:15:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:29:14 2008''

Revision as of 02:29, 28 July 2008

Image:1w78.png

Template:STRUCTURE 1w78

E.COLI FOLC IN COMPLEX WITH DHPP AND ADP

Template:ABSTRACT PUBMED 15705579

About this Structure

1W78 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Escherichia coli FolC structure reveals an unexpected dihydrofolate binding site providing an attractive target for anti-microbial therapy., Mathieu M, Debousker G, Vincent S, Viviani F, Bamas-Jacques N, Mikol V, J Biol Chem. 2005 May 13;280(19):18916-22. Epub 2005 Feb 10. PMID:15705579

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