9vkw

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Current revision (08:25, 11 December 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9vkw is ON HOLD until Paper Publication
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==Cryo-EM structure of the NuA3 complex bound to Ace-coenzyme A==
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<StructureSection load='9vkw' size='340' side='right'caption='[[9vkw]], [[Resolution|resolution]] 3.13&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9vkw]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9VKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9VKW FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.13&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9vkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9vkw OCA], [https://pdbe.org/9vkw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9vkw RCSB], [https://www.ebi.ac.uk/pdbsum/9vkw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9vkw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SAS3_YEAST SAS3_YEAST] Catalytic component of the NuA3 histone acetyltransferase complex, that acetylates H3K14 (PubMed:10600516, PubMed:10817755, PubMed:11731478, PubMed:16581777, PubMed:17157260, PubMed:25104842). The NuA3 HAT complex has 2 functionally distinct forms. NuA3a binds H3K4me3, through the PHD finger of YNG1, and acetylates H3K14 at the promoter region of actively transcribed genes to promote transcription initiation. NuA3b binds H3K36me3 at the coding regions of actively transcribed genes, through the PWWP domain of PDP3, and coordinates transcription elongation (PubMed:17157260, PubMed:25104842). In vitro, SAS3 acetylates free histones H3 and H4 (PubMed:10600516). It is involved in silencing the HMR locus (PubMed:16581777, PubMed:8782818).<ref>PMID:10600516</ref> <ref>PMID:10817755</ref> <ref>PMID:11731478</ref> <ref>PMID:16581777</ref> <ref>PMID:17157260</ref> <ref>PMID:25104842</ref> <ref>PMID:8782818</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Wang YR]]
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[[Category: Zhang HQ]]

Current revision

Cryo-EM structure of the NuA3 complex bound to Ace-coenzyme A

PDB ID 9vkw

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