1b5e
From Proteopedia
(New page: 200px<br /> <applet load="1b5e" size="450" color="white" frame="true" align="right" spinBox="true" caption="1b5e, resolution 1.60Å" /> '''DCMP HYDROXYMETHYLA...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1B5E is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ ]] with DCM as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.8 2.1.2.8]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1B5E OCA]]. | + | 1B5E is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Enterobacteria_phage_t2 Enterobacteria phage t2]] with DCM as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Deoxycytidylate_5-hydroxymethyltransferase Deoxycytidylate 5-hydroxymethyltransferase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.8 2.1.2.8]]. Structure known Active Site: CAT. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1B5E OCA]]. |
==Reference== | ==Reference== | ||
Crystal structure of deoxycytidylate hydroxymethylase from bacteriophage T4, a component of the deoxyribonucleoside triphosphate-synthesizing complex., Song HK, Sohn SH, Suh SW, EMBO J. 1999 Mar 1;18(5):1104-13. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10064578 10064578] | Crystal structure of deoxycytidylate hydroxymethylase from bacteriophage T4, a component of the deoxyribonucleoside triphosphate-synthesizing complex., Song HK, Sohn SH, Suh SW, EMBO J. 1999 Mar 1;18(5):1104-13. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10064578 10064578] | ||
| + | [[Category: Deoxycytidylate 5-hydroxymethyltransferase]] | ||
| + | [[Category: Enterobacteria phage t2]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Sohn, S.H.]] | [[Category: Sohn, S.H.]] | ||
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[[Category: hydroxymethylase]] | [[Category: hydroxymethylase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:00:50 2007'' |
Revision as of 09:56, 30 October 2007
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DCMP HYDROXYMETHYLASE FROM T4
Overview
Bacteriophage T4 deoxycytidylate hydroxymethylase (EC 2.1.2.8), a, homodimer of 246-residue subunits, catalyzes hydroxymethylation of the, cytosine base in deoxycytidylate (dCMP) to produce 5-hydroxymethyl-dCMP., It forms part of a phage DNA protection system and appears to function in, vivo as a component of a multienzyme complex called deoxyribonucleoside, triphosphate (dNTP) synthetase. We have determined its crystal structure, in the presence of the substrate dCMP at 1.6 A resolution. The structure, reveals a subunit fold and a dimerization pattern in common with, thymidylate synthases, despite low (approximately 20%) sequence identity., Among the residues that form the dCMP binding site, those interacting with, the sugar and phosphate are arranged in a configuration similar to the, ... [(full description)]
About this Structure
1B5E is a [Single protein] structure of sequence from [Enterobacteria phage t2] with DCM as [ligand]. Active as [Deoxycytidylate 5-hydroxymethyltransferase], with EC number [2.1.2.8]. Structure known Active Site: CAT. Full crystallographic information is available from [OCA].
Reference
Crystal structure of deoxycytidylate hydroxymethylase from bacteriophage T4, a component of the deoxyribonucleoside triphosphate-synthesizing complex., Song HK, Sohn SH, Suh SW, EMBO J. 1999 Mar 1;18(5):1104-13. PMID:10064578
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