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1w7g

From Proteopedia

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[[Image:1w7g.gif|left|200px]]
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{{Seed}}
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[[Image:1w7g.png|left|200px]]
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{{STRUCTURE_1w7g| PDB=1w7g | SCENE= }}
{{STRUCTURE_1w7g| PDB=1w7g | SCENE= }}
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'''ALPHA-THROMBIN COMPLEX WITH SULFATED HIRUDIN (RESIDUES 54-65) AND L-ARGININE TEMPLATE INHIBITOR CS107'''
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===ALPHA-THROMBIN COMPLEX WITH SULFATED HIRUDIN (RESIDUES 54-65) AND L-ARGININE TEMPLATE INHIBITOR CS107===
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==Overview==
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Piperazinyl-amide derivatives of N-alpha-(3-trifluoromethyl-benzenesulfonyl)-L-arginine (1) were synthesized as graftable thrombin inhibitors. The possible disturbance of biological activity due to a variable spacer-arm fixed on the N-4 piperazinyl position was evaluated in vitro, against human alpha-thrombin, and in blood coagulation assay. Molecular modelling (in silico analysis) and X-ray diffraction studies of thrombin-inhibitor complexes were also performed. The fixation of bioactive molecules on poly(butylene terephthalate) (PBT) and poly(ethylene terephthalate) (PET) membranes was performed by wet chemistry treatment and evaluated by XPS analysis. Surface grafting of inhibitor 1d improved the membrane hemocompatibility by reducing blood clot formation on the modified surface.
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The line below this paragraph, {{ABSTRACT_PUBMED_16294249}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16294249 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16294249}}
==About this Structure==
==About this Structure==
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[[Category: Serine protease]]
[[Category: Serine protease]]
[[Category: Thrombin]]
[[Category: Thrombin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:15:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:00:22 2008''

Revision as of 14:00, 28 July 2008

Image:1w7g.png

Template:STRUCTURE 1w7g

ALPHA-THROMBIN COMPLEX WITH SULFATED HIRUDIN (RESIDUES 54-65) AND L-ARGININE TEMPLATE INHIBITOR CS107

Template:ABSTRACT PUBMED 16294249

About this Structure

1W7G is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Design, synthesis and evaluation of graftable thrombin inhibitors for the preparation of blood-compatible polymer materials., Salvagnini C, Michaux C, Remiche J, Wouters J, Charlier P, Marchand-Brynaert J, Org Biomol Chem. 2005 Dec 7;3(23):4209-20. Epub 2005 Oct 19. PMID:16294249

Page seeded by OCA on Mon Jul 28 17:00:22 2008

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