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1w7l

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{{STRUCTURE_1w7l| PDB=1w7l | SCENE= }}
{{STRUCTURE_1w7l| PDB=1w7l | SCENE= }}
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'''CRYSTAL STRUCTURE OF HUMAN KYNURENINE AMINOTRANSFERASE I'''
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===CRYSTAL STRUCTURE OF HUMAN KYNURENINE AMINOTRANSFERASE I===
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==Overview==
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The kynurenine pathway has long been regarded as a valuable target for the treatment of several neurological disorders accompanied by unbalanced levels of metabolites along the catabolic cascade, kynurenic acid among them. The irreversible transamination of kynurenine is the sole source of kynurenic acid, and it is catalyzed by different isoforms of the 5'-pyridoxal phosphate-dependent kynurenine aminotransferase (KAT). The KAT-I isozyme has also been reported to possess beta-lyase activity toward several sulfur- and selenium-conjugated molecules, leading to the proposal of a role of the enzyme in carcinogenesis associated with environmental pollutants. We solved the structure of human KAT-I in its 5'-pyridoxal phosphate and pyridoxamine phosphate forms and in complex with the competing substrate l-Phe. The enzyme active site revealed a striking crown of aromatic residues decorating the ligand binding pocket, which we propose as a major molecular determinant for substrate recognition. Ligand-induced conformational changes affecting Tyr(101) and the Trp(18)-bearing alpha-helix H1 appear to play a central role in catalysis. Our data reveal a key structural role of Glu(27), providing a molecular basis for the reported loss of enzymatic activity displayed by the equivalent Glu --&gt; Gly mutation in KAT-I of spontaneously hypertensive rats.
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(as it appears on PubMed at http://www.pubmed.gov), where 15364907 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15364907}}
==About this Structure==
==About this Structure==
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[[Category: Pyridoxal phosphate]]
[[Category: Pyridoxal phosphate]]
[[Category: Transferase.]]
[[Category: Transferase.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:16:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:28:44 2008''

Revision as of 13:28, 28 July 2008

Image:1w7l.png

Template:STRUCTURE 1w7l

CRYSTAL STRUCTURE OF HUMAN KYNURENINE AMINOTRANSFERASE I

Template:ABSTRACT PUBMED 15364907

About this Structure

1W7L is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human kynurenine aminotransferase I., Rossi F, Han Q, Li J, Li J, Rizzi M, J Biol Chem. 2004 Nov 26;279(48):50214-20. Epub 2004 Sep 10. PMID:15364907

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