Glutamate receptor 3D structures

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*Ionotropic glutamate receptor 1
*Ionotropic glutamate receptor 1
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**[[3saj]] - rIGluR1 ATD – rat<br />
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**[[8c1p]], [[8c1q]], [[8c2h]], [[8c2i]], [[8p3q]], [[8p3t]], [[8p3u]], [[8p3v]], [[8p3x]] – rIGluR1 + calcium channel γ2 subunit – rat - Cryo-EM<br />
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**[[5ict]] – DmIGluR1 LBD (mutant) – ''Drosophila melanogaster'' <br />
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**[[5dt6]] – DmIGluR1 LBD (mutant) + glutamate <br />
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**[[4io2]] – AvIGluR1 LBD + Glu – ''Adineta vaga''<br />
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**[[4io3]], [[4io4]], [[4io5]], [[4io6]], [[4io7]] – AvIGluR1 LBD + amino acid<br />
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*Ionotropic glutamate receptor 2 (GluR2) or AMPA receptor GluA2
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**[[2wjw]], [[2wjx]] – hIGluR2 ATD - human<br />
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**[[3rn8]], [[3rnn]] – hIGluR2 LBD + potentiator<br />
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**[[5ybf]], [[5ybg]] - hIGluR2 LBD + potentiator + Glu<br />
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**[[4u1y]], [[4u2p]], [[5l1b]] - rIGluR2 <br />
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**[[6dlz]], [[7rz9]], [[9b68]], [[9b69]] – rGluR2 – Cryo EM <br />
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**[[3n6v]], [[3o2j]], [[5n6p]] - rIGluR2 ATD (mutant) – rat<br />
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**[[3h5v]], [[3h5w]], [[3hsy]] - rIGluR2 ATD<br />
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**[[3bki]], [[5l1e]], [[5l1f]], [[5l1g]], [[5l1h]] - rIGluR2 LBD + inhibitor<br />
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**[[1fto]], [[4h8j]] - rIGluR2 LBD<br />
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**[[3t93]], [[4u2r]] - rIGluR2 LBD (mutant)<br />
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**[[5fth]], [[5fti]], [[5ns9]] - rIGluR2 LBD (mutant) + Glu<br />
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**[[5kbs]], [[5kbt]], [[5kbu]] - rIGluR2 + antagonist – Cryo-EM<br />
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**[[5kk2]], [[5vot]], [[5vou]], [[5vov]] - rIGluR2 + calcium channel γ2 subunit – Cryo-EM<br />
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**[[8piv]], [[9b5z]], [[9b60]], [[9b61]], [[9b63]], [[9b64]], [[9b67]], [[9b6a]], [[9dhp]], [[9dhq]], [[9dhr]], [[9dhs]], [[9dht]], [[9mrk]], [[9mrl]], [[9mrm]], [[9mrn]] - rIGluR2 + calcium channel γ2 subunit – Cryo-EM<br />
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**[[8c1r]], [[8p3s]], [[8p3w]], [[8p3y]], [[8p3z]] - rIGluR2 (mutant) + calcium channel γ2 subunit – Cryo-EM<br />
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**[[9e4z]] - rIGluR2 + calcium channel γ2 subunit + inhibitor – Cryo-EM<br />
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**[[9e4y]] - rIGluR2 + calcium channel γ2 subunit + Glu + inhibitor – Cryo-EM<br />
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**[[8ss9]] - rIGluR2 + calcium channel γ2 subunit + competitive antagonist + drug – Cryo-EM<br />
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**[[8ss4]] - rIGluR2/calcium channel γ2 subunit + cornichon + channel blocker – Cryo-EM<br />
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**[[8ssa]], [[8ssb]] - rIGluR2/calcium channel γ2 subunit + cornichon + Glu + channel blocker – Cryo-EM<br />
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**[[8ss6]] - rIGluR2/calcium channel γ2 subunit + cornichon + Glu + channel blocker + drug – Cryo-EM<br />
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**[[8ss2]] - rIGluR2/calcium channel γ2 subunit + cornichon + competitive antagonist + channel blocker – Cryo-EM<br />
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**[[6ucb]], [[6ud4]], [[6ud8]] - rIGluR2 + CNIH-3 + antagonist – Cryo-EM<br />
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**[[8vj6]] - rIGluR2 + Glu + antagonist – Cryo-EM<br />
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*''GluR2 allosteric modulator complex''
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**[[2xhd]], [[5h8s]] - hIGluR2 LBD + positive allosteric modulator + Glu<br />
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**[[1p1o]], [[2al4]] - rIGluR2 LBD (mutant) + quisqualate<br />
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**[[3ijo]], [[3ijx]], [[3il1]], [[3ilt]], [[3ilu]], [[3lsl]], [[3m3l]], [[3o28]], [[3o29]], [[3o2a]], [[3o6g]], [[3o6h]], [[3o6i]], [[3pmv]], [[3pmw]], [[3pmx]] [[3tdj]], [[5oew]], [[6hch]], [[6hcc]], [[6hcb]], [[6hc9]], [[6faz]] - rIGluR2 + positive allosteric modulator + Glu<br />
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**[[2xx8]], [[2xx7]], [[2xx9]], [[2xxh]], [[2xxi]], [[3bbr]], [[3lsf]], [[3h6t]], [[3h6u]], [[3h6v]], [[3h6w]], [[3tkd]], [[4fat]], [[4iy5]], [[4iy6]], [[4lz5]], [[4lz7]], [[4lz8]], [[4n07]], [[5o9a]] - rIGluR2 LBD (mutant) + positive allosteric modulator + Glu<br />
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**[[6hca]] - rIGluR2 LBD + positive allosteric modulator<br />
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**[[1mm6]], [[1mm7]] - rIGluR2 LBD + quisqualate<br />
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**[[3ik6]] - rIGluR2 + Duiril + Glu<br />
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**[[6ruq]] - rIGluR2 extracellular domain (mutant) + antagonist + negative allosteric modulator<br />
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*''GluR2 antagonist complex''
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 +
**[[6peq]] - hIGluR2 + CNIH-3 + antagonist – Cryo EM<br />
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**[[3r7x]], [[6fqi]], [[6fqj]], [[6fqk]] - hIGluR2 LBD + antagonist<br />
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**[[6fqg]], [[6fqh]] - hIGluR2 LBD (mutant) + antagonist<br />
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**[[2cmo]], [[3kg2]], [[3kgc]] - rIGluR2 LBD + antagonist + Glu<br />
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**[[4u4g]], [[6u5s]], [[6u6i]] - rIGluR2 + antagonist<br />
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A [[Glutamate receptor (GluA2)|topic page]] describing in detail the [[Glutamate receptor (GluA2)|GluA2 structure described in 3kg2]]<br />
 +
**[[1ftl]], [[1n0t]], [[3b7d]], [[3h03]], [[3h06]], [[3tza]], [[3ua8]], [[4isu]], [[5cbr]], [[5cbs]], [[4yma]], [[6xsr]], [[6yk2]], [[6yk3]], [[6yk4]], [[6yk5]], [[6yk6]] - rIGluR2 LBD + antagonist<br />
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**[[1lb9]], [[4l17]], [[4u21]], [[4u22]], [[4u23]], [[5kbv]] - rIGluR2 LBD (mutant) + antagonist<br />
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**[[5wek]], [[7rz4]], [[7rz5]] – rGluR2 + antagonist – Cryo EM <br />
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*''GluR2 agonist complex''
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**[[1ftm]], [[1m5b]], [[1m5c]], [[1m5d]], [[1m5e]], [[1m5f]], [[1mqd]], [[1ms7]], [[1nnk]], [[1nnp]], [[1wvj]], [[1syh]], [[1syi]], [[3bft]], [[3bfu]], [[3pd8]], [[3pd9]], [[3rtf]], [[3rtw]], [[4g8m]], [[4igt]], [[4q30]], [[4x48]], [[5fhm]], [[5fhn]] [[5fho]], [[5ng9]], [[5nih]], [[5vhw]], [[5vhx]], [[5vhy]], [[6q60]], [[6q54]], [[8i0b]] - rIGluR2 LBD + agonist<br />
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**[[5vhz]] - rIGluR2 LBD + quisqualate<br />
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**[[1lb8]], [[1p1q]], [[1p1u]], [[1p1w]], [[2al5]], [[2anj]] - rIGluR2 LBD (mutant) + agonist<br />
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**[[3b6t]] - rIGluR2 LBD (mutant) + quisqualate<br />
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**[[1lbc]], [[5elv]] - rIGluR2 LBD (mutant) + agonist + Glu<br />
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**[[2p2a]], [[5buu]], [[6hcb]], [[6hcc]], [[6hch]] - rIGluR2 LBD + agonist + Glu<br />
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**[[7ryy]], [[7ryz]], [[7rz7]], [[7rz8]], [[7rza]] – rGluR2 + quisqualate – Cryo EM <br />
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*''GluR2 partial agonist complex''
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**[[5zg2]] - hIGluR2 + partial agonist <br />
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**[[5ybf]], [[5ybg]], [[5zg0]], [[5zg1]], [[5zg3]] - hIGluR2 + partial agonist + Glu<br />
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**[[4u4f]] - rIGluR2 + partial agonist<br />
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**[[1ftk]], [[1fw0]], [[1gr2]], [[1mqg]], [[1mqh]], [[1mqi]], [[1mqj]], [[1mxu]], [[1mxv]], [[1mxw]], [[1mxx]], [[1mxy]], [[1mxz]], [[1my0]], [[1my1]], [[1my2]], [[1my3]], [[1my4]], [[1y1m]], [[1y1z]], [[1y20]], [[2aix]] - rIGluR2 LBD + partial agonist<br />
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**[[1lbb]], [[1p1n]], [[1xhy]], [[3t96]], [[3t9h]], [[3t9u]], [[3t9v]], [[5jei]] - rIGluR2 LBD (mutant) + partial agonist<br />
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**[[4u2q]] - rIGluR2 + partial agonist<br />
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**[[4u5b]], [[4u5c]], [[4u5d]], [[4u5e]], [[4u5f]] - rIGluR2 + partial agonist + snail toxin + modulator<br />
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**[[4gxs]], [[4u1o]], [[4u1w]], [[4u1x]], [[4u1z]] - rIGluR2 LBD + kainate derivative<br />
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*''GluR2 ligand complex''
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**[[8fp4]], [[8fp9]], [[8fpc]], [[8fpg]], [[8fph]], [[8fpk]], [[8fpl]], [[8fps]], [[8fpv]], [[8fpy]], [[8fpz]], [[8fr0]] - rGluR2 + Glu – Cryo EM<br />
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**[[7f3o]] - hIGluR2 LBD + Glu + antagonist<br />
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**[[1ftj]], [[2i3v]], [[2i3w]], [[2uxa]], [[3dp6]], [[4o3b]], [[4z0i]], [[6gl4]] - rIGluR2 LBD + Glu<br />
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**[[2gfe]], [[3b6q]], [[3b6w]], [[3t9x]], [[4u4s]], [[4u4x]], [[4yu0]], [[6giv]] - rIGluR2 LBD (mutant) + Glu<br />
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**[[4o3a]], [[4o3c]] - rIGluR2 LBD + Asp<br />
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**[[4u1o]], [[4u1w]], [[4u1x]], [[4u1z]] - rIGluR2 LBD + kainate derivative<br />
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**[[4uq6]], [[4uqj]], [[4uqk]] - rIGluR2 + quisqualate – Cryo EM<br />
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**[[4wxj]] - DmIGluR2 LBD + Glu<br />
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*Ionotropic glutamate receptor 3
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**[[9hpc]], [[9hpd]], [[9hpe]], [[9hpf]], [[9hpk]], [[9qfh]] – rGluR3/calcium channel γ-8 – Cryo EM <br />
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**[[3o21]], [[3p3w]], [[6flr]], [[6fpj]] – rIGluR3 ATD<br />
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**[[3m3k]] – rIGluR3 LBD<br />
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**[[3dp4]], [[3rt6]], [[3rt8]] – rIGluR3 LBD + agonist<br />
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**[[3m3f]] – rIGluR3 LBD + allosteric modulator<br />
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**[[3dln]] - rIGluR3 LBD + Glu<br />
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**[[4f1y]] - rIGluR3 LBD + CNQX<br />
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**[[4f22]], [[4f39]], [[4f3g]] - rIGluR3 LBD + kainate<br />
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**[[4f31]] - rIGluR3 LBD (mutant) + kainate<br />
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**[[4f29]] - rIGluR3 LBD + quisqualate<br />
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**[[4f2o]], [[4f2q]] - rIGluR3 LBD (mutant) + quisqualate<br />
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**[[4f3b]] - rIGluR3 LBD (mutant) + Glu<br />
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**[[4zdm]] – GluR3 LBD + Gly – ''Pleurobrachia bachei''<br />
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*Ionotropic glutamate receptor 3.2
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**[[6x5q]] – AtIGluR3.2 LBD + Gly – ''Arabidopsis thaliana''<br />
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*Ionotropic glutamate receptor 3.3
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**[[6r88]] – AtIGluR3.3 LBD<br />
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**[[6r85]] – AtIGluR3.3 LBD + Glu <br />
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**[[6r89]], [[6r8a]] – AtIGluR3.3 LBD + amino acid <br />
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*Ionotropic glutamate receptor 3.4
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**[[7lzi]] – AtIGluR3.4 – Cryo EM<br />
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**[[7lzh]] – AtIGluR3.4 + Glu – Cryo EM<br />
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**[[7lz1]] – AtIGluR3.4 + Ser<br />
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**[[7lz0]] – AtIGluR3.4 LBD + Glu<br />
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**[[7lz2]] – AtIGluR3.4 LBD + Met<br />
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*Ionotropic glutamate receptor δ or GluD
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**[[5kc8]] – hIGluRδ2 ATD<br />
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**[[8blj]] – hIGluRδ1 LBD <br />
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**[[8bn5]] – hIGluRδ1 LBD + GABA<br />
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**[[8bn2]] – hIGluRδ1 LBD + Ser<br />
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**[[5kc9]] – IGluRδ1 C-terminal - mouse <br />
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**[[6ksp]], [[6kss]] – rIGluRδ1 extracellular domain – Cryo EM<br />
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**[[5l2e]] – rIGluRδ2 extracellular domain<br />
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**[[6lu9]] – rIGluRδ2 extracellular domain – Cryo EM<br />
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**[[7z2r]] – rIGluRd2 LBD <br />
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**[[5cc2]] – rIGluRδ2 LBD + agonist<br />
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*Ionotropic glutamate receptor 1+2 or AMPA receptor
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**[[7occ]] – rIGluR1 + rGluR2 – Cryo EM <br />
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**[[6qkc]], [[6qkz]], [[7ocd]], [[7qhh]], [[8ayl]], [[8aym]], [[8ayn]], [[8ayo]] – rIGluR1 + rGluR2 + calcium channel γ-8 – Cryo EM <br />
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**[[7oca]], [[7oce]], [[7ocf]] – rIGluR1 + rGluR2 + calcium channel γ-8 + CNIH2 – Cryo EM <br />
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**[[5weo]], [[7tnk]], [[7tnl]], [[7tnm]], [[7tnn]], [[7tno]], [[7tnp]] – rIGluR1/calcium channel g-8 + drug – Cryo EM <br />
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**[[6njl]] – rIGluR1 + rGluR2 + calcium channel γ-8 + scFv + auxiliary protein + antibody – Cryo EM <br />
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**[[7rz5]] – rGluR2 + antagonist – Cryo EM <br />
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**[[8c1s]] – rGluR2 + calcium channel γ-8 – Cryo EM <br />
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**[[8ss5]] – rGluR2/calcium channel γ-8 – Cryo EM <br />
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**[[8ss8]] – rGluR2/calcium channel γ-8 + antagonist – Cryo EM <br />
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**[[7qhb]], [[7rz6]], [[8fqd]], [[8fqg]], [[8fqh]] – rGluR2 + Glu – Cryo EM <br />
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**[[6dm1]], [[6o9g]] – rGluR2 + Glu + inhibitor – Cryo EM <br />
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**[[6zyu]], [[8fq1]], [[8fq2]], [[8fq3]], [[8fq5]], [[8fq6]], [[8fq8]], [[8fqa]], [[8fqb]] – rGluR2 LBD + Glu + inhibitor<br />
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**[[8fqf]] – rGluR2 + Glu – Cryo EM <br />
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**[[6dm0]] – rGluR2 + Glu + drug – Cryo EM <br />
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**[[7tnj]] – rGluR2 + drug – Cryo EM <br />
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**[[6ovd]], [[6ove]] – rIGluR1 + rGluR2 residues 415-821 + antagonist<br />
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**[[7ldd]], [[7lde]] – mIGluR1 + mGluR2 + calcium channel γ-8 + SCFV + antibody – Cryo EM <br />
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*Ionotropic glutamate receptor 1+4
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**[[9nr7]], [[9nra]] – rIGluR1 + rGluR4 + voltage dependent calcium channel + auxiliary protein – Cryo EM <br />
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**[[9nr9]] – rIGluR1 + rGluR4 + voltage dependent calcium channel – Cryo EM <br />
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**[[9nr6]], [[9nr8]] – rIGluR1 ATD + rGluR4 + scFv – Cryo EM <br />
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*Ionotropic glutamate receptor 1+2+3
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**[[6njn]] – rIGluR1 + rGluR2 + rIGluR3 + calcium channel g-8 + auxiliary protein + antibody – Cryo EM <br />
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*Ionotropic glutamate receptor 2+3
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**[[5fwy]], [[5ide]], [[5idf]] – rIGluR2 + rGluR3 <br />
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**[[6njm]] – rGluR2 + rIGluR3 + calcium channel γ-8 + auxiliary protein + antibody – Cryo EM <br />
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*Ionotropic glutamate receptor 2+4
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**[[8wgd]] – hIGluR2 + hIGluR4 – Cryo EM <br />
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**[[5fwx]] – rIGluR2 ATD + rIGluR4 ATD <br />
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*Ionotropic glutamate receptor 1+2+3+4
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**[[7lep]] – rIGluR1 + rGluR2 + rIGluR3 + rGluR4 + calcium channel γ-8 + CNIH2 – Cryo EM <br />
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*Ionotropic glutamate receptor 4
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**[[3epe]], [[3fas]] - rIGluR4 LBD + Glu<br />
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**[[3kei]] – rIGluR4 LBD (mutant) + Glu<br />
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**[[3kfm]] - rIGluR4 LBD (mutant) + partial agonist<br />
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**[[3en3]] - rIGluR4 LBD + partial agonist<br />
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**[[3fat]] – rIGluR4 LBD + agonist<br />
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**[[4gpa]] – rIGluR4 ATD <br />
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*Ionotropic glutamate receptor 5
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**[[2zns]], [[3fuz]] – hIGluR5 LBD + Glu<br />
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**[[2znt]], [[2znu]], [[3fv1]], [[3fv2]], [[3fvg]], [[3fvk]], [[3fvn]], [[3fvo]] - hIGluR5 LBD + agonist<br />
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**[[1txf]] - rIGluR5 LBD + Glu<br />
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**[[2ojt]] - rIGluR5 + anion<br />
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**[[3c31]], [[3c32]], [[3c33]], [[3c34]], [[3c35]], [[3c36]] - rIGluR5 LBD + ion<br />
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**[[2f34]], [[2f35]], [[2f36]], [[2pbw]], [[2wky]], [[3gba]], [[3gbb]] – rIGluR5 LBD + agonist<br />
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**[[2qs1]], [[2qs2]], [[2qs3]], [[2qs4]] - rIGluR5 LBD (mutant) + agonist<br />
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**[[1vso]] - rIGluR5 LBD + antagonist<br />
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*Ionotropic glutamate receptor 6
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**[[3h6g]], [[3h6h]] – rIGluR6 ATD<br />
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**[[1s50]], [[1s7y]], [[1sd3]], [[3g3f]] – rIGluR6 LBD + Glu<br />
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**[[2i0b]], [[2i0c]], [[3g3g]], [[3g3h]], [[3g3i]], [[3g3j]], [[3g3k]] - rIGluR6 LBD (mutant) + Glu<br />
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**[[1s9t]] – rIGluR6 LBD + quisqualate<br />
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**[[1tt1]] – rIGluR6 LBD + partial agonist<br />
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*Metabotropic glutamate receptor see [[Metabotropic glutamate receptor]]
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*Ionotropic kainate receptor 1
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**[[8gpr]] – rGluK1 – Cryo EM<br />
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**[[7lvt]] – rGluK1 + Glu – Cryo EM<br />
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**[[7ysj]], [[7ysv]] – rGluK1 extracellular domain (mutant) – Cryo EM<br />
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**[[1ycj]] – rGluK1 LBD + Glu<br />
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**[[5neb]], [[5nf5]] – rGluK1 LBD + Glu analog<br />
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**[[3s2v]], [[4dld]], [[4mf3]], [[4qf9]], [[4ymb]], [[5m2v]], [[6fz4]], [[6sbt]] – rGluK1 LBD + antagonist<br />
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**[[4e0x]] – rGluK1 LBD + kainate<br />
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**[[5mfq]], [[5mfv]], [[5mfw]] – rGluK1 LBD + kainite + allosteric modulator<br />
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*Ionotropic kainate receptor 2; LBD + TM 1-908
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**[[9c5y]], [[9c5z]], [[9c60]], [[9caz]] - rGluK2 – Cryo EM<br />
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**[[8f0o]] - rGluK2 (mutant) – Cryo EM<br />
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**[[7f56]], [[7f57]], [[7f59]], [[7f5a]], [[7f5b]] - rGluK2 (mutant) + NETO2 – Cryo EM<br />
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**[[9b38]], [[9b39]] - rGluK2 + Glu – Cryo EM<br />
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**[[8fws]] – rGluK2 + modulator – Cryo EM<br />
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**[[9dxq]], [[9dxr]], [[9dxs]], [[9dxt]] – rGluK2 + channel blocker + modulator – Cryo EM<br />
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**[[9b36]], [[9b37]] – rGluK2 + concanavalin A + modulator + Glu – Cryo EM<br />
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**[[8fwu]] – rGluK2 + modulator + competitive antagonist – Cryo EM<br />
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**[[8ss9]] – rGluK2 + + competitive antagonist + drug – Cryo EM<br >
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**[[8ss7]] – rGluK2 + channel blocker + competitive antagonist + drug – Cryo EM<br />
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**[[3qxm]] - hGluK2 LBD + toxin<br />
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**[[2xxr]] – rGluK2 LBD + Glu<br />
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**[[8r32]] – rGluK2 LBD + Glu + modulator<br />
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**[[8r36]] – rGluK2 LBD + kainate + modulator<br />
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**[[9b35]] – rGluK2 LBD + Glu + modulator – Cryo EM<br />
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**[[8qez]] – rGluK2 LBD (mutant) + Glu + modulator<br />
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**[[4h8i]], [[5cmm]] - rGluK2 LBD + Glu derivative<br />
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**[[2xxu]], [[2xxw]], [[2xxx]], [[4bdl]], [[4bdn]], [[4bdq]], [[5cmk]] – rGluK2 LBD (mutant) + Glu<br />
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**[[4bdm]], [[4bdo]], [[4bdr]] – rGluK2 LBD (mutant) + kainate <br />
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**[[8gc2]], [[8gc3]], [[8gc4]], [[8gc5]] – rGluK2 + partial agonist – Cryo EM<br />
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**[[2xxt]] – rGluK2 LBD + partial agonist<br />
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**[[2xxv]], [[2xxy]] – rGluK2 LBD (mutant) + partial agonist<br />
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**[[3qlt]] - rGluK2 residues 32-420 (mutant)<br />
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**[[1yae]], [[5kuf]] - rGluK2 LBD + agonist<br />
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**[[5kuh]] - rGluK2 LBD (mutant) + agonist<br />
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**[[8fwq]], [[8fwr]] - rGluK2 LBD+TM + modulator – Cryo EM<br />
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**[[8fwv]], [[8fww]] - rGluK2 LBD+TM + modulator + drug – Cryo EM<br />
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**[[8fwt]] - rGluK2 LBD+TM + modulator + antagonist – Cryo EM<br />
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**[[4uqq]] - rGluK2 ATD,LBD,TMD (mutant) + agonist<br />
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*Ionotropic kainate receptor 3
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**[[6jfy]], [[6jfz]], [[6kzm]], [[6l6f]], [[7vm2]] - rGluK3 (mutant) – Cryo EM<br />
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**[[3olz]] – rGluK3 ATD<br />
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**[[6fjy]], [[6fjz]] - rGluK3 extracellular domain (mutant)<br />
 +
**[[6kzm]], [[6l6f]] - rGluK3 extracellular domain (mutant) – Cryo EM<br />
 +
**[[3s9e]], [[3u93]], [[3u94]], [[4mh5]] – rGluK3 LBD + Glu<br />
 +
**[[5nf6]] - rGluK3 LBD + Glu analog<br />
 +
**[[6jmv]] - rGluK3 LBD + Glu derivative<br />
 +
**[[3u92]], [[4e0w]] - rGluK3 LBD + kainate br />
 +
**[[8bst]] - rGluK3 LBD (mutant) + kainate br />
 +
**[[8bsu]] - rGluK3 LBD + kainite + modulator<br />
 +
**[[4g8n]], [[4igr]], [[4nwc]], [[4nwd]], [[5o4f]] - rGluK3 LBD + agonist<br />
 +
**[[6f28]], [[6f29]] - rGluK3 LBD + pyrimidine derivative<br />
 +
 +
*Ionotropic kainate receptor 4
 +
 +
**[[5ikb]] – rGluK4 LBD + kainate<br />
 +
 +
*Ionotropic kainate receptor 5
 +
 +
**[[3om0]], [[3om1]] – rGluK5 ATD<br />
 +
 +
*Ionotropic kainate receptor 2+5
 +
 +
**[[7ks3]] – rGluK2 + rGluK5 – Cryo EM<br />
 +
**[[7ks0]] – rGluK2 + rGluK5 + inhibitor – Cryo EM<br />
 +
**[[3qlu]] - rGluK5 + rGluK2 (mutant)<br />
 +
**[[3qlv]] - rGluK5 + rGluK2
 +
 +
*NMDA receptor (NMDAR)
 +
 +
*''NMDAR subunit NR1''
 +
 +
**[[2nr1]] – hNMDAR TMD - NMR<br />
 +
**[[4kcc]] – rNMDAR LBD <br />
 +
**[[3q41]] – rNMDAR N ATD <br />
 +
**[[1y1m]], [[1y1z]], [[1y20]] – NMDAR LBD (mutant) + partial agonist<br />
 +
**[[1pb7]] – rNMDAR LBD + glycine<br />
 +
**[[1pb8]], [[1pb9]] – rNMDAR LBD + serine<br />
 +
**[[1pbq]] – rNMDAR LBD + DCKA<br />
 +
**[[4kfq]], [[9gib]], [[9gic]], [[9gid]], [[9gie]], [[9gif]], [[9gig]], [[9gj1]] – rNMDAR LBD + antagonist<br />
 +
**[[5fxg]], [[5fxh]], [[5fxi]], [[5fxk]] – rNMDAR (mutant) – Cryo EM<br />
 +
**[[3qek]] – XlNMDA R ATD (mutant) – ''Xenopus laevis''<br />
 +
 +
*''NMDAR subunit NR2A''
 +
 +
**[[2a5s]] - rNMDAR LBD + glutamate<br />
 +
**[[4jwx]], [[6odl]] – rNMDAR LBD + agonist<br />
 +
 +
*''NMDAR subunit NR2B''
 +
 +
**[[7ujq]] - hNMDAR 1289-1310 + CAMK2A <br />
 +
**[[7kl0]], [[7kl2]], [[7uis]] - hNMDAR 1289-1310 (mutant) + CAMK2A <br />
 +
**[[7ujs]] - hNMDAR 1289-1310 + CAMK2A + ADP<br />
 +
**[[7ujp]] - hNMDAR 1289-1310 + CAMK2A + ATP<br />
 +
**[[7kl1]], [[7ujt]] - hNMDAR 1289-1310 (mutant) + CAMK2A + ATP<br />
 +
**[[3jpw]], [[3jpy]] - rNMDAR ATD (mutant)<br />
 +
**[[7ujr]] - rNMDAR 1289-1310 + CAMK2A <br />
 +
**[[5uow]], [[5up2]] - XlNMDAR + NR2A + Fab + Glu – Cryo-EM<br />
 +
**[[5un1]] - XlNMDAR + methyl-aspartate receptor + Glu <br />
 +
 +
*''NMDAR subunit NR3A''
 +
 +
**[[4kcd]] – rNMDAR LBD <br />
 +
**[[2rc8]] - rNMDAR LBD + serine<br />
 +
**[[2rc7]], [[2rca]] - rNMDAR LBD + glycine<br />
 +
**[[2rc9]] - rNMDAR LBD + ACPC<br />
 +
 +
*''NMDAR subunit NR3B''
 +
 +
**[[2rcb]] - rNMDAR LBD + serine<br />
 +
 +
*''NMDAR subunit NR2D''
 +
 +
**[[4jwy]] – rNMDAR LBD + agonist<br />
 +
**[[3oek]], [[3oem]] – rNMDAR LBD + aspartate<br />
 +
**[[3oel]], [[3oen]] – rNMDAR LBD + glutamate<br />
 +
 +
*''NMDAR subunit NR1+NR2A''
 +
 +
**[[7eos]], [[7eou]] – hNMDAR (mutant) – Cryo EM<br />
 +
**[[5h8f]] – hNMDAR LBD <br />
 +
**[[8vul]] – hNMDAR ATD – Cryo EM <br />
 +
**[[6ira]], [[6irf]], [[6irg]], [[6irh]], [[6mm9]], [[6mma]], [[6mmb]], [[6mmg]], [[6mmh]], [[6mmi]], [[6mmj]], [[6mmk]], [[6mml]], [[6mmm]], [[6mmn]], [[6mmp]], [[6mmr]], [[6mms]], [[6mmt]], [[6mmu]], [[6mmv]], [[6mmw]], [[6mmx]] – rNMDAR – Cryo EM <br />
 +
**[[2a5t]], [[4nf4]], [[4nf5]], [[4nf6]], [[4nf8]] – rNMDAR LBD <br />
 +
**[[5tpz]] – XlNMDAR ATD <br />
 +
 +
*''NMDAR subunit NR1+NR2A complex''
 +
 +
**[[5tp9]], [[5tpa]] – hNMDAR LBD + antagonist<br />
 +
**[[7eoq]], [[7eor]], [[7eot]] – hNMDAR (mutant) + antagonist – Cryo EM<br />
 +
**[[5kcj]], [[5kdt]] – hNMDAR LBD + modulator<br />
 +
**[[5h8h]], [[5h8n]], [[5h8q]], [[5i2k]], [[5i2n]] [[5kcj]], [[5kdt]], [[5tp9]], [[5tpa]] – hNMDAR LBD + allosteric modulator<br />
 +
**[[9mul]], [[9mum]] – hNMDAR LBD + Glu + Gly + inhibitor<br />
 +
**[[8jiz]], [[8jj1]], [[8vuj]], [[8vun]] – hNMDAR + antibody – Cryo EM<br />
 +
**[[8vur]] – hNMDAR + IgG – Cryo EM <br />
 +
**[[5dex]], [[5u8c]], [[5vih]], [[5vii]], [[5vij]] – rNMDAR LBD + antagonist<br />
 +
**[[6usu]], [[9da9]] – rNMDAR LBD + antagonist + Glu<br />
 +
**[[6usv]] – rNMDAR LBD + antagonist + Gly<br />
 +
**[[6uz6]] – rNMDAR LBD (mutant) + antagonist + Glu + Gly<br />
 +
**[[6uzr]], [[6uzw]] – rNMDAR LBD + antagonist + Gly<br />
 +
**[[6uzg]], [[6uzx]] – rNMDAR LBD (mutant) + antagonist + Gly<br />
 +
**[[5fxj]], [[5jty]] – rNMDAR + agonist<br />
 +
**[[8jj0]], [[8jj2]] – rNMDAR + antibody – Cryo EM<br />
 +
**[[8vuq]], [[8vuv]] – rNMDAR ATD + antibody – Cryo EM<br />
 +
**[[8vuh]], [[8vus]] – rNMDAR + IgG – Cryo EM <br />
 +
**[[5tq0]], [[5tq2]] – rNMDAR LBD + antibody<br />
 +
**[[5i56]], [[5i57]], [[5i58]], [[5i59]] – rNMDAR LBD + allosteric modulator<br />
 +
**[[5tpw]], [[5tq0]], [[5tq2]] – XlNMDAR1 ATD (mutant) + rNMDAR2A LBD + antibody<br />
 +
**[[5tpw]] – XlNMDAR1 LBD (mutant) + rNMDAR2A LBD + antibody<br />
 +
**[[5ewl]], [[5ewm]] – XlNMDAR1 ATD (mutant) + rNMDAR2A ATD (mutant) + antagonist<br />
 +
 +
*''NMDAR subunit NR1+NR2B''
 +
 +
**[[9iyp]], [[9iyq]] – hNMDAR – Cryo EM <br />
 +
**[[6cna]], [[9arg]], [[9jnn]] – rNMDAR – Cryo EM <br />
 +
**[[5tpz]] – rNMDAR LBD <br />
 +
**[[6wi0]] – rNMDAR + antagonist – Cryo EM <br />
 +
**[[7te9]], [[7teb]], [[7tee]], [[7teq]], [[7tes]], [[8vvh]], [[8vuu]] – rNMDAR + antibody – Cryo EM <br />
 +
**[[8vut]] – rNMDAR + IgG – Cryo EM <br />
 +
**[[7eu7]], [[7eu8]], [[7sac]] – rNMDAR + ketamine + Glu – Cryo EM <br />
 +
**[[7saa]], [[9ari]] – rNMDAR + Glu – Cryo EM <br />
 +
**[[9arh]] – rNMDAR + Gly – Cryo EM <br />
 +
**[[7yfl]], [[9bib]] – rNMDAR + Glu + Gly – Cryo EM <br />
 +
**[[9are]], [[9arf]] – rNMDAR + Glu + Gly + inhibitor – Cryo EM <br />
 +
**[[7sab]] – rNMDAR + PCP – Cryo EM <br />
 +
**[[7sad]] – rNMDAR + drug – Cryo EM <br />
 +
**[[4pe5]], [[4tll]], [[4tlm]] – rNMDAR (mutants)<br />
 +
**[[5b3j]] – XlNMDAR1 ATD (mutant) + rNMDAR2B ATD (mutant) + antibody<br />
 +
**[[5un1]] – XlNMDAR LBD+TMD<br />
 +
**[[5iov]], [[5iou]], [[5ipq]], [[5ipr]], [[5ips]], [[5ipt]], [[5ipv]] – rNMDAR2B (mutant) + NMDAR1 + inhibitor<br />
 +
**[[5ipu]], [[6e7r]], [[6e7s]], [[6e7t]], [[6e7u]], [[6e7v]], [[6e7w]], [[6e7x]] – XlNMDAR2B (mutant) + NMDAR1 (mutant) + inhibitor<br />
 +
**[[3qel]], [[3qem]], [[5ewj]] – XlNMDAR ATD (mutant) + ifenprodil<br />
 +
 +
*''NMDAR subunit NR1+NR2C''
 +
 +
**[[8e94]], [[8e97]] – hNMDAR – Cryo EM <br />
 +
**[[8e92]], [[8e93]], [[8e96]], [[8e98]] – hNMDAR + Glu + cyclo-Ser – Cryo EM <br />
 +
**[[7yfg]], [[7yfh]], [[8hdk]] – rNMDAR + Glu + Gly – Cryo EM <br />
 +
 +
*''NMDAR subunit NR1+NR2D''
 +
 +
**[[7yfo]], [[7yfr]] – hNMDAR – Cryo EM <br />
 +
**[[7yff]] – rNMDAR + CPP + Gly – Cryo EM <br />
 +
 +
*''NMDAR subunit NR1+NR2A+NR2C''
 +
 +
**[[8e99]] – hNMDAR + nanobody – Cryo EM <br />
 +
 +
*''NMDAR subunit NR1B+NR2B''
 +
 +
**[[6whr]], [[6whs]], [[6wht]], [[6whu]], [[6whv]], [[6wi1]] – rNMDAR – Cryo EM <br />
 +
**[[6whw]], [[6whx]], [[6why]] – rNMDAR + antagonist – Cryo EM <br />
 +
**[[7ter]], [[7tet]], [[8vuy]] – rNMDAR + antibody – Cryo EM <br />
 +
**[[7te6]] – rNMDAR ATD + antibody <br />
 +
**[[8g18]] – rNMDAR ATD + inhibitor<br />
 +
 +
*''NMDAR subunit NR1B+NR2D''
 +
 +
**[[8y1v]] – hNMDAR + competitive antagonist + inhibitor – Cryo EM <br />
 +
**[[7yfm]] – rNMDAR + Glu + Gly – Cryo EM <br />
 +
 +
*''NMDAR subunit NR1+NR2A+NR2B''
 +
 +
**[[8xlk]] – rNMDAR – Cryo EM <br />
 +
**[[5uow]], [[5up2]] – XlNMDAR + antibody – Cryo EM<br />
 +
 +
*''NMDAR subunit NR1+NR2B+NR2D''
 +
 +
**[[9d37]], [[9d3a]] – hNMDAR + Glu + Gly – Cryo EM <br />
 +
**[[9d39]] – hNMDAR + PPDA + Gly – Cryo EM <br />
 +
**[[9d3c]] – hNMDAR + Glu + Gly + ketamine – Cryo EM <br />
 +
**[[9d38]], [[9d3b]] – hNMDAR + Glu + Gly + inhibitor – Cryo EM <br />
 +
 +
*''NMDAR subunit NR1+NR2A+NR2C''
 +
 +
**[[7yfi]] – rNMDAR + Glu + Gly – Cryo EM <br />
 +
 +
*''NMDAR subunit NR1+NR2A+NR3A''
 +
 +
**[[8jf7]] – rNMDAR + Glu + Gly + antibody – Cryo EM <br />
 +
 +
*''NMDAR subunit NR1+NR3A''
 +
 +
**[[8usw]] – hNMDAR + inhibitor – Cryo EM <br />
 +
**[[8usx]], [[8uue]] – rNMDAR + Gly – Cryo EM <br />
 +
}}
 +
 +
[[Category:Topic Page]]
 +
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**[[3saj]] - rIGluR1 ATD – rat<br />
**[[3saj]] - rIGluR1 ATD – rat<br />

Current revision

3D structures of glutamate receptor

Updated on 16-July-2025

A topic page describing in detail the GluA2 structure described in 3kg2









    • 3saj - rIGluR1 ATD – rat
    • 5ict – DmIGluR1 LBD (mutant) – Drosophila melanogaster
    • 5dt6 – DmIGluR1 LBD (mutant) + glutamate
    • 4io2 – AvIGluR1 LBD + Glu – Adineta vaga
    • 4io3, 4io4, 4io5, 4io6, 4io7 – AvIGluR1 LBD + amino acid
  • Ionotropic glutamate receptor 2 (GluR2)
  • GluR2 allosteric modulator complex
  • GluR2 antagonist complex

A topic page describing in detail the GluA2 structure described in 3kg2

  • GluR2 agonist complex
  • GluR2 partial agonist complex
  • GluR2 ligand complex
  • Ionotropic glutamate receptor 3
    • 3o21, 3p3w, 6fpj, 6flr – rIGluR3 ATD
    • 3m3k – rIGluR3 LBD
    • 3rt6, 3rt8, 3dp4 – rIGluR3 LBD + agonist
    • 3m3f – rIGluR3 LBD + allosteric modulator
    • 3dln - rIGluR3 LBD + Glu
    • 4f1y - rIGluR3 LBD + CNQX
    • 4f22, 4f39, 4f3g - rIGluR3 LBD + kainate
    • 4f31 - rIGluR3 LBD (mutant) + kainate
    • 4f29 - rIGluR3 LBD + quisqualate
    • 4f2o, 4f2q - rIGluR3 LBD (mutant) + quisqualate
    • 4f3b - rIGluR3 LBD (mutant) + Glu
    • 4zdm – GluR3 LBD + Gly – Pleurobrachia bachei
  • Ionotropic glutamate receptor 3.2
    • 6x5q – AtIGluR3.2 LBD + Gly – Arabidopsis thaliana
  • Ionotropic glutamate receptor 3.3
    • 6r88 – AtIGluR3.3 LBD
    • 6r85 – AtIGluR3.3 LBD + Glu
    • 6r89, 6r8a – AtIGluR3.3 LBD + amino acid
  • Ionotropic glutamate receptor 3.4
    • 7lzi – AtIGluR3.4 – Cryo EM
    • 7lzh – AtIGluR3.4 + Glu – Cryo EM
  • Ionotropic glutamate receptor δ or GluD
    • 5kc8 – hIGluRδ2 ATD
    • 5kc9 – IGluRδ1 C-terminal - mouse
    • 6ksp, 6kss – rIGluRδ1 extracellular domain – Cryo EM
    • 5l2e – rIGluRδ2 extracellular domain
    • 6lu9 – rIGluRδ2 extracellular domain – Cryo EM
    • 7z2r – rIGluRd2 LBD
    • 5cc2 – rIGluRδ2 LBD + agonist
  • Ionotropic glutamate receptor 1+2 or AMPA receptor
    • 7occ – rIGluR1 + rGluR2 – Cryo EM
    • 6qkz, 6qkc, 7ocd, 7qhh, 8ayl, 8ayn – rIGluR1 + rGluR2 + calcium channel γ-8 – Cryo EM
    • 7oca, 7oce, 7ocf – rIGluR1 + rGluR2 + calcium channel γ-8 + CNIH2 – Cryo EM
    • 5weo, 7tnk, 7tnl, 7tnm, 7tnn, 7tno, 7tnp – rIGluR1/calcium channel g-8 + drug – Cryo EM
    • 6njl – rIGluR1 + rGluR2 + calcium channel γ-8 + SCFV + auxiliary protein + antibody – Cryo EM
    • 7ryz, 7rz8 – rGluR2 + agonist – Cryo EM
    • 7rz5 – rGluR2 + antagonist – Cryo EM
    • 7qhb, 7rz6 – rGluR2 + Glu – Cryo EM
    • 6dm1, 6o9g – rGluR2 + Glu + inhibitor – Cryo EM
    • 6dm0 – rGluR2 + Glu + drug – Cryo EM
    • 7tnj – rGluR2 + drug – Cryo EM
    • 6zyu – rGluR2 LBD + Glu + inhibitor
    • 6ovd, 6ove – rIGluR1 + rGluR2 residues 415-821 + antagonist
    • 7ldd, 7lde – mIGluR1 + mGluR2 + calcium channel γ-8 + SCFV + antibody – Cryo EM
  • Ionotropic glutamate receptor 1+2+3
    • 6njn – rIGluR1 + rGluR2 + rIGluR3 + calcium channel g-8 + auxiliary protein + antibody – Cryo EM
  • Ionotropic glutamate receptor 2+3
    • 5ide, 5idf, 5fwy – rIGluR2 + rGluR3
    • 6njm – rGluR2 + rIGluR3 + calcium channel γ-8 + auxiliary protein + antibody – Cryo EM
  • Ionotropic glutamate receptor 2+4
    • 5fwx – rIGluR2 ATD + rIGluR4 ATD
  • Ionotropic glutamate receptor 1+2+3+4
    • 7lep – rIGluR1 + rGluR2 + rIGluR3 + rGluR4 + calcium channel γ-8 + CNIH2 – Cryo EM
  • Ionotropic glutamate receptor 4
    • 3epe, 3fas - rIGluR4 LBD + Glu
    • 3kei – rIGluR4 LBD (mutant) + Glu
    • 3kfm - rIGluR4 LBD (mutant) + partial agonist
    • 3en3 - rIGluR4 LBD + partial agonist
    • 3fat – rIGluR4 LBD + agonist
    • 4gpa – rIGluR4 ATD
  • Ionotropic glutamate receptor 5
  • Ionotropic glutamate receptor 6
  • Ionotropic kainate receptor 1
  • Ionotropic kainate receptor 2; LBD + TM 1-908
    • 7f56, 7f57, 7f59, 7f5a, 7f5b - rGluK2 (mutant) + NETO2 – Cryo EM
    • 3qxm - hGluK2 LBD + toxin
    • 2xxr – rGluK2 LBD + Glu
    • 4h8i, 5cmm - rGluK2 LBD + Glu derivative
    • 2xxu, 2xxx, 2xxw, 4bdl, 4bdn, 4bdq, 5cmk – rGluK2 LBD (mutant) + Glu
    • 4bdm, 4bdo, 4bdr – rGluK2 LBD (mutant) + kainate
    • 2xxt – rGluK2 LBD + partial agonist
    • 2xxv, 2xxy – rGluK2 LBD (mutant) + partial agonist
    • 3qlt - rGluK2 residues 32-420 (mutant)
    • 1yae, 5kuf - rGluK2 LBD + agonist
    • 5kuh - rGluK2 LBD (mutant) + agonist
    • 8fwq, 8fwr - rGluK2 LBD+TM + modulator – Cryo EM
    • 8fwv, 8fww - rGluK2 LBD+TM + modulator + drug – Cryo EM
    • 8fwt - rGluK2 LBD+TM + modulator + antagonist – Cryo EM
    • 4uqq - rGluK2 ATD,LBD,TMD (mutant) + agonist
  • Ionotropic kainate receptor 3
  • Ionotropic kainate receptor 4
    • 5ikb – rGluK4 LBD + kainate
  • Ionotropic kainate receptor 5
  • Ionotropic kainate receptor 2+5
    • 7ks3 – rGluK2 + rGluK5 – Cryo EM
    • 7ks0 – rGluK2 + rGluK5 + inhibitor – Cryo EM
    • 3qlu - rGluK5 + rGluK2 (mutant)
    • 3qlv - rGluK5 + rGluK2
  • NMDA receptor (NMDAR)
  • NMDAR subunit NR1
    • 2nr1 – hNMDAR TMD - NMR
    • 4kcc – rNMDAR LBD
    • 3q41 – rNMDAR N ATD
    • 1y1m, 1y1z, 1y20 – NMDAR LBD (mutant) + partial agonist
    • 1pb7 – rNMDAR LBD + glycine
    • 1pb8, 1pb9 – rNMDAR LBD + serine
    • 1pbq – rNMDAR LBD + DCKA
    • 4kfq – rNMDAR LBD + antagonist
    • 5fxk, 5fxi, 5fxh, 5fxg – rNMDAR (mutant) – Cryo EM
    • 3qek – XlNMDA R ATD (mutant) – Xenopus laevis
  • NMDAR subunit NR2A
    • 2a5s - rNMDAR LBD + glutamate
    • 4jwx, 6odl – rNMDAR LBD + agonist
  • NMDAR subunit NR2B
    • 7ujq - hNMDAR 1289-1310 + CAMK2A
    • 7kl0, 7kl2, 7uis - hNMDAR 1289-1310 (mutant) + CAMK2A
    • 7ujs - hNMDAR 1289-1310 + CAMK2A + ADP
    • 7ujp - hNMDAR 1289-1310 + CAMK2A + ATP
    • 7ujt, 7kl1 - hNMDAR 1289-1310 (mutant) + CAMK2A + ATP
    • 3jpy, 3jpw - rNMDAR ATD (mutant)
    • 7ujr - rNMDAR 1289-1310 + CAMK2A
    • 5up2, 5uow - XlNMDAR + NR2A + Fab + Glu – Cryo-EM
    • 5un1 - XlNMDAR + methyl-aspartate receptor + Glu
  • NMDAR subunit NR3A
    • 4kcd – rNMDAR LBD
    • 2rc8 - rNMDAR LBD + serine
    • 2rc7, 2rca - rNMDAR LBD + glycine
    • 2rc9 - rNMDAR LBD + ACPC
  • NMDAR subunit NR3B
    • 2rcb - rNMDAR LBD + serine
  • NMDAR subunit NR2D
    • 4jwy – rNMDAR LBD + agonist
    • 3oek, 3oem – rNMDAR LBD + aspartate
    • 3oel, 3oen – rNMDAR LBD + glutamate
  • NMDAR subunit NR1+NR2A
  • NMDAR subunit NR1+NR2A complex
  • NMDAR subunit NR1+NR2B
  • NMDAR subunit NR1+NR2C
  • NMDAR subunit NR1+NR2D
    • 7yfo, 7yfr – hNMDAR – Cryo EM
    • 7yff – rNMDAR + CPP + Gly – Cryo EM
  • NMDAR subunit NR1+NR2A+NR2C
    • 8e99 – hNMDAR + nanobody – Cryo EM
  • NMDAR subunit NR1B+NR2B
  • NMDAR subunit NR1B+NR2D
    • 7yfm – rNMDAR + Glu + Gly – Cryo EM
  • NMDAR subunit NR1+NR2A+NR2B
    • 5up2, 5uow – XlNMDAR + antibody – Cryo EM
  • NMDAR subunit NR1+NR2A+NR2C
    • 7yfi – rNMDAR + Glu + Gly – Cryo EM

}}

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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