9rvp

Structural highlights

Function

Q88595_TMEVG Affects membrane integrity and causes an increase in membrane permeability.[ARBA:ARBA00004017] Associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities.[ARBA:ARBA00024707] Cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate cooperatively bind to the protease. Cleaves host PABP1, this cleavage is important for viral replication.[ARBA:ARBA00059332] Forms a primer, VPg-pU, which is utilized by the polymerase for the initiation of RNA chains.[ARBA:ARBA00002520] Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. Together they form an icosahedral capsid composed of 60 copies of each VP1, VP2, and VP3, with a diameter of approximately 300 Angstroms. VP4 lies on the inner surface of the protein shell formed by VP1, VP2 and VP3. All the three latter proteins contain a beta-sheet structure called beta-barrel jelly roll. VP1 is situated at the 12 fivefold axes, whereas VP2 and VP3 are located at the quasi-sixfold axes.[ARBA:ARBA00059502] Lies on the inner surface of the capsid shell. After binding to the host receptor, the capsid undergoes conformational changes. Capsid protein VP4 is released, capsid protein VP1 N-terminus is externalized, and together, they shape a pore in the host membrane through which the viral genome is translocated into the host cell cytoplasm. After genome has been released, the channel shrinks.[ARBA:ARBA00033716] Replicates the genomic and antigenomic RNAs by recognizing replications specific signals. Performs VPg uridylylation.[ARBA:ARBA00045446] Serves as membrane anchor via its hydrophobic domain.[ARBA:ARBA00003704] VP0 precursor is a component of immature procapsids.[ARBA:ARBA00002982]