1w9o

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{{STRUCTURE_1w9o| PDB=1w9o | SCENE= }}
{{STRUCTURE_1w9o| PDB=1w9o | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE PDZ TANDEM OF HUMAN SYNTENIN IN COMPLEX WITH TNEYYV PEPTIDE'''
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===CRYSTAL STRUCTURE OF THE PDZ TANDEM OF HUMAN SYNTENIN IN COMPLEX WITH TNEYYV PEPTIDE===
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==Overview==
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PDZ domains are among the most abundant protein modules in the known genomes. Their main function is to provide scaffolds for membrane-associated protein complexes by binding to the cytosolic, C-terminal fragments of receptors, channels, and other integral membrane proteins. Here, using both heteronuclear NMR and single crystal X-ray diffraction, we show how peptides with different sequences, including those corresponding to the C-termini of syndecan, neurexin, and ephrin B, can simultaneously bind to both PDZ domains of the scaffolding protein syntenin. The PDZ2 domain binds these peptides in the canonical fashion, and an induced fit mechanism allows for the accommodation of a range of side chains in the P(0) and P(-)(2) positions. However, binding to the PDZ1 domain requires that the target peptide assume a noncanonical conformation. These data help explain how syntenin, and perhaps other PDZ-containing proteins, may preferentially bind to dimeric and clustered targets, and provide a mechanistic explanation for the previously reported cooperative ligand binding by syntenin's two PDZ domains.
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(as it appears on PubMed at http://www.pubmed.gov), where 16533050 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16533050}}
==About this Structure==
==About this Structure==
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[[Category: Pdz domain]]
[[Category: Pdz domain]]
[[Category: Scaffolding protein]]
[[Category: Scaffolding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:21:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:14:23 2008''

Revision as of 10:14, 29 July 2008

Image:1w9o.png

Template:STRUCTURE 1w9o

CRYSTAL STRUCTURE OF THE PDZ TANDEM OF HUMAN SYNTENIN IN COMPLEX WITH TNEYYV PEPTIDE

Template:ABSTRACT PUBMED 16533050

About this Structure

1W9O is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The binding of the PDZ tandem of syntenin to target proteins., Grembecka J, Cierpicki T, Devedjiev Y, Derewenda U, Kang BS, Bushweller JH, Derewenda ZS, Biochemistry. 2006 Mar 21;45(11):3674-83. PMID:16533050

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