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1w9n

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[[Image:1w9n.gif|left|200px]]
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{{STRUCTURE_1w9n| PDB=1w9n | SCENE= }}
{{STRUCTURE_1w9n| PDB=1w9n | SCENE= }}
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'''ISOLATION AND CHARACTERIZATION OF EPILANCIN 15X, A NOVEL ANTIBIOTIC FROM A CLINICAL STRAIN OF STAPHYLOCOCCUS EPIDERMIDIS'''
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===ISOLATION AND CHARACTERIZATION OF EPILANCIN 15X, A NOVEL ANTIBIOTIC FROM A CLINICAL STRAIN OF STAPHYLOCOCCUS EPIDERMIDIS===
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==Overview==
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The potential application of lantibiotics as food-preserving agents and more recently as antibiotics has strongly increased the interest in these antibacterial peptides. Here, we report the elucidation of the primary and three-dimensional structures of the novel lantibiotic epilancin 15X from Staphylococcus epidermidis using high-resolution nuclear magnetic resonance spectroscopy and tandem mass spectrometry. The molecule contains ten post-translationally modified amino acids, three lanthionine ring structures and a hydroxy-propionyl N-terminal moiety. The primary and tertiary structure and the distribution of positive charges are closely similar to the previously identified lantibiotic epilancin K7, most likely indicative of a common mode of action.
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(as it appears on PubMed at http://www.pubmed.gov), where 15792796 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15792796}}
==About this Structure==
==About this Structure==
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1W9N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9N OCA].
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1W9N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9N OCA].
==Reference==
==Reference==
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[[Category: Lanthionine-ring]]
[[Category: Lanthionine-ring]]
[[Category: Lantibiotic]]
[[Category: Lantibiotic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:21:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:02:59 2008''

Revision as of 14:03, 28 July 2008

Image:1w9n.png

Template:STRUCTURE 1w9n

ISOLATION AND CHARACTERIZATION OF EPILANCIN 15X, A NOVEL ANTIBIOTIC FROM A CLINICAL STRAIN OF STAPHYLOCOCCUS EPIDERMIDIS

Template:ABSTRACT PUBMED 15792796

About this Structure

1W9N is a Single protein structure of sequence from Staphylococcus epidermidis. Full experimental information is available from OCA.

Reference

Isolation and structural characterization of epilancin 15X, a novel lantibiotic from a clinical strain of Staphylococcus epidermidis., Ekkelenkamp MB, Hanssen M, Danny Hsu ST, de Jong A, Milatovic D, Verhoef J, van Nuland NA, FEBS Lett. 2005 Mar 28;579(9):1917-22. PMID:15792796

Page seeded by OCA on Mon Jul 28 17:02:59 2008

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