1w9r

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[[Image:1w9r.gif|left|200px]]
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{{Seed}}
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[[Image:1w9r.png|left|200px]]
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{{STRUCTURE_1w9r| PDB=1w9r | SCENE= }}
{{STRUCTURE_1w9r| PDB=1w9r | SCENE= }}
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'''SOLUTION STRUCTURE OF CHOLINE BINDING PROTEIN A, DOMAIN R2, THE MAJOR ADHESIN OF STREPTOCOCCUS PNEUMONIAE'''
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===SOLUTION STRUCTURE OF CHOLINE BINDING PROTEIN A, DOMAIN R2, THE MAJOR ADHESIN OF STREPTOCOCCUS PNEUMONIAE===
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==Overview==
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Streptococcus pneumoniae (pneumococcus) remains a significant health threat worldwide, especially to the young and old. While some of the biomolecules involved in pneumococcal pathogenesis are known and understood in mechanistic terms, little is known about the molecular details of bacterium/host interactions. We report here the solution structure of the 'repeated' adhesion domains (domains R1 and R2) of the principal pneumococcal adhesin, choline binding protein A (CbpA). Further, we provide insights into the mechanism by which CbpA binds its human receptor, polymeric immunoglobulin receptor (pIgR). The R domains, comprised of 12 imperfect copies of the leucine zipper heptad motif, adopt a unique 3-alpha-helix, raft-like structure. Each pair of alpha-helices is antiparallel and conserved residues in the loop between Helices 1 and 2 exhibit a novel 'tyrosine fork' structure that is involved in binding pIgR. This and other structural features that we show are conserved in most pneumococcal strains appear to generally play an important role in bacterial adhesion to pIgR. Interestingly, pneumococcus is the only bacterium known to adhere to and invade human cells by binding to pIgR.
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(as it appears on PubMed at http://www.pubmed.gov), where 15616594 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15616594}}
==About this Structure==
==About this Structure==
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1W9R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9R OCA].
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1W9R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9R OCA].
==Reference==
==Reference==
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[[Category: Pigr]]
[[Category: Pigr]]
[[Category: Polymeric immunoglobulin receptor]]
[[Category: Polymeric immunoglobulin receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:21:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:21:18 2008''

Revision as of 09:21, 27 July 2008

Image:1w9r.png

Template:STRUCTURE 1w9r

SOLUTION STRUCTURE OF CHOLINE BINDING PROTEIN A, DOMAIN R2, THE MAJOR ADHESIN OF STREPTOCOCCUS PNEUMONIAE

Template:ABSTRACT PUBMED 15616594

About this Structure

1W9R is a Single protein structure of sequence from Streptococcus pneumoniae. Full experimental information is available from OCA.

Reference

Solution structure of choline binding protein A, the major adhesin of Streptococcus pneumoniae., Luo R, Mann B, Lewis WS, Rowe A, Heath R, Stewart ML, Hamburger AE, Sivakolundu S, Lacy ER, Bjorkman PJ, Tuomanen E, Kriwacki RW, EMBO J. 2005 Jan 12;24(1):34-43. Epub 2004 Dec 16. PMID:15616594

Page seeded by OCA on Sun Jul 27 12:21:18 2008

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