1wan

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{{STRUCTURE_1wan| PDB=1wan | SCENE= }}
{{STRUCTURE_1wan| PDB=1wan | SCENE= }}
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'''DNA DTA TRIPLEX, NMR, 7 STRUCTURES'''
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===DNA DTA TRIPLEX, NMR, 7 STRUCTURES===
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==Overview==
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We have used NMR spectroscopy to study a pyrimidine-purine-pyrimidine DNA triplex containing a non-natural base, 1-(2-deoxy-beta-D-ribofuranosyl)-4-(3-benzamido)phenylimidazole (D3), in the third strand. The D3 base has been previously shown to specifically recognize T-A and C-G base-pairs via intercalation on the 3' side (with respect to the purine strand) of the target base pair, instead of forming sequence-specific hydrogen bonds. 1H resonance assignments have been made for the D3 base and most of the non-loop portion of the triplex. The solution structure of the triplex was calculated using restrained molecular dynamics and complete relaxation matrix refinement. The duplex portion of the triplex has an over-all helical structure that is more similar to B-DNA than to A-DNA. The three aromatic rings of the D3 base stack on the bases of all three strands and mimic a triplet. The conformation of the D3 base and its sequence specificity are discussed.
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The line below this paragraph, {{ABSTRACT_PUBMED_8632468}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8632468 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8632468}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WAN OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WAN OCA].
==Reference==
==Reference==
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[[Category: Intercalator]]
[[Category: Intercalator]]
[[Category: Triplex]]
[[Category: Triplex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:23:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:19:13 2008''

Revision as of 03:19, 28 July 2008

Image:1wan.png

Template:STRUCTURE 1wan

DNA DTA TRIPLEX, NMR, 7 STRUCTURES

Template:ABSTRACT PUBMED 8632468

About this Structure

Full experimental information is available from OCA.

Reference

Solution structure of a pyrimidine-purine-pyrimidine triplex containing the sequence-specific intercalating non-natural base D3., Wang E, Koshlap KM, Gillespie P, Dervan PB, Feigon J, J Mol Biol. 1996 Apr 19;257(5):1052-69. PMID:8632468

Page seeded by OCA on Mon Jul 28 06:19:13 2008

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